Sequencing an individual’s DNA seems destined to become an increasingly prominent part of medical care. Once a genetic alteration has been identified and characterized by researchers, testing for it is relatively simple, requiring only white blood cells obtained via a routine blood draw. Because so many diseases are influenced by heredity, investigators are likely to identify numerous alterations associated with illness in the human genome. In the past, genetic testing concerned the next generation: decisions about whether to have a child (eg, TaySachs disease, cystic fibrosis, and Down syndrome) and screening of newborns (eg, phenylketonuria and sickle cell anemia). Increasingly, genetic testing now concerns the current generation: testing ourselves for susceptibility to chronic disease. This domain includes more common conditions (eg, heart disease, diabetes, and cancer) and a future has been promised in which medicine’s emphasis will be shifted from treatment of the sick to prevention in those at risk. 1 But the immediate future is more likely to be characterized by confusion. The confusion created by false-positive and false-negative tests will be familiar to clinicians. A less familiar source of confusion will also be present: because the absence of a genetic risk factor will rarely (if ever) reduce risk much below average, those with truly negative test results must be reminded that they remain at risk. However, the greatest challenge is what to tell those with truly positive test results. These persons may be best characterized as “pre-patients.” In this article, we examine 4 uncertainties that clinicians will have to communicate to prepatients: the nature of risk, the generalizability of risk estimates, the time at which risk information is useful, and the utility of intervention.