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Background Gastric cancer (GC) is a prevalent malignancy, leading to a high incidence of cancer-associated death. Cisplatin (DDP)-based chemotherapy is the principal therapy for clinical GC treatment, but DDP resistance is a severe clinical challenge and the mechanism remains poorly understood. Circular RNAs (circRNAs) have been identified to play crucial roles in modulating the chemoresistance of gastric cancer cells. Aim To explore the effect of circVAPA on chemotherapy resistance during GC progression. Methods The effect of circVAPA on GC progression and chemotherapy resistance was analyzed by MTT assay, colony formation assay, Transwell assay, wound healing assay, and flow cytometry analysis in GC cells and DDP resistant GC cell lines, and tumorigenicity analysis in nude mice in vivo. The mechanism was investigated by luciferase reporter assay, quantitative real-time PCR, and Western blot analysis. Results CircVAPA expression was up-regulated in clinical GC tissues compared with normal samples. CircVAPA depletion inhibited proliferation, migration, and invasion and increased apoptosis of GC cells. The expression of circVAPA, STAT3, and STAT3 downstream genes was elevated in DDP resistant SGC7901/DDP cell lines. CircVAPA knockdown attenuated the DDP resistance of GC cells. Mechanically, circVAPA was able to sponge miR-125b-5p, and miR-125b-5p could target STAT3 in the GC cells. MiR-125b-5p inhibitor reversed circVAPA depletion-enhanced inhibitory effect of DDP on GC cells, and STAT3 knockdown blocked circVAPA overexpression-induced proliferation of DDP-treated SGC7901/DDP cells. The depletion of STAT3 and miR-125b-5p inhibitor reversed circVAPA depletion-induced GC cell apoptosis. Functionally, circVAPA contributed to the tumor growth of SGC7901/DDP cells in vivo. Conclusion CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling. Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells. CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy.

Catalytic combustion technology can effectively reduce the temperature of the combustion reaction and significantly inhibit the formation of NOx. Perovskites catalyst materials have high stability, varied chemical composition, and low cost etc. A combination of catalytic combustion technology and perovskite catalyst materials has great significance for energy industry and environment protection. However, improving lower temperature catalytic activity and high temperature thermostability performance of perovskite catalyst is still major problem. Some researchers have improved the activity and stability of perovskite catalysts for methane combustion by different preparation methods. The structure and preparation methods of perovskite-type oxide catalysts are presented.

This article discusses the NMT communities on the impact of urban environment and social issues, proposing the main problems existing in NMT communities are follows: The NMT paths are lack of systematic; the wide of NMT is not enough; mixed with the motor transportation; NMT environmental quality is not high. Then put forward some design methods: Set up a network of NMT combining with community environment; build up the NMT landscape suitable to human scale; community facilities design for NMT.

As the important component of urban environment, urban wetland is always intimately related with the development of the city and peoples lives. However, along with the more attention to the zoology recover and reconstruction of urban wetland, the wetland plannings become common with others, and lack of the expression of Genius Loci. Therefore, its pressed for setting up wetland landscape combined with zoology and humanism in city area. The article puts forward the methods of expression of Genius Loci by means of reasonable wetland planning, various and abundant wetland space forms, taking full advantage of natural environment elements and so on.

The significance of energy-saving and emission-reduction in architectural design of university campus was described. And the problems of energy waste in architectural design of campus were analyzed. Finally, the measures of energy-saving and emission-reduction in architectural design of Campus are put forward, including the design in the building orientation and graphic, roof and external retaining structure, shape coefficient, new technology and material, system, water supply and drainage system, structural design, and the use of renewable energy etc.