39 results on '"Yasuhiro Nakano"'
Search Results
2. Temporal artery thickening in giant cell arteritis
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Fumio Otsuka, Hiromi Ihoriya, and Yasuhiro Nakano
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Pathology ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,medicine.diagnostic_test ,business.industry ,Biopsy ,Giant Cell Arteritis ,General Medicine ,medicine.disease ,Temporal Arteries ,Jaw claudication ,Giant cell arteritis ,medicine ,Blood test ,Humans ,Temporal artery ,Thickening ,business ,Vasculitis ,Temporal pain - Abstract
A 74-year-old woman presented with fever, jaw claudication and bilateral temporal pain lasting for 1 week. On examination, the bilateral temporal arteries (TAs) were nodularly swollen, tender and hypopulsatile ([figure 1A][1]). A blood test showed elevated white cell count (9.33×109/L), high
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- 2023
3. Trends in Long COVID Symptoms in Japanese Teenage Patients
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Yasue Sakurada, Yuki Otsuka, Kazuki Tokumasu, Naruhiko Sunada, Hiroyuki Honda, Yasuhiro Nakano, Yui Matsuda, Toru Hasegawa, Kanako Ochi, Hideharu Hagiya, Keigo Ueda, Hitomi Kataoka, and Fumio Otsuka
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Delta variant ,teenagers ,schoolchildren ,General Medicine ,Omicron variant ,post-COVID-19 condition - Abstract
Background: Since the start of the global pandemic of coronavirus disease 2019 (COVID-19), not only adults but also many children have suffered from it. However, the clinical characteristics of long COVID in children remain unclear. Methods: In this retrospective observational study conducted in a single facility, we reviewed the medical records of all long COVID patients who visited Okayama University Hospital from February 2021 to October 2022, and we compared the clinical characteristics of long COVID in teenagers (11 to 18 years of age) with those in adults. Results: Data for 452 long COVID patients including 54 teenagers (11.9%) were analyzed. Fatigue was the most frequent symptom in teenagers (55.6% of the patients) and also in adults. On the other hand, the percentage of teenagers who complained of headache, which was the second most frequent complaint, was significantly higher than the percentage of adults (35.2% vs. 21.9%, p < 0.05). A comparison of the frequencies of symptoms depending on the viral variant showed that fatigue and headache were predominant symptoms in the Omicron variant phase. Of the 50 teenagers who were enrolled in schools, 28 (56.0%) could not attend school due to long COVID symptoms. The most common symptoms as reasons for absence from school were fatigue (85.7% of the patients), headache (42.9%), and insomnia (32.1%). Conclusions: Attention should be paid to the symptoms of fatigue and headache in teenagers with long COVID.
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- 2023
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4. Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan
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Naruhiko Sunada, Yasuhiro Nakano, Yuki Otsuka, Kazuki Tokumasu, Hiroyuki Honda, Yasue Sakurada, Yui Matsuda, Toru Hasegawa, Daisuke Omura, Kanako Ochi, Hideharu Hagiya, Keigo Ueda, Hitomi Kataoka, and Fumio Otsuka
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myalgic encephalomyelitis ,insomnia ,General Medicine ,Omicron variant ,long COVID ,chronic fatigue ,post COVID-19 condition - Abstract
Objectives: The objective of this study was to determine the clinical and endocrinological features of sleep disturbance in patients with long COVID. Methods: This study was a single-center retrospective observational study for patients who visited the COVID-19 aftercare outpatient clinic (CAC) established in Okayama University Hospital in Japan during the period from 15 February 2021 to 29 July 2022. The long COVID patients were divided into two groups based on the presence or absence of sleep disturbance, and the clinical and laboratory characteristics of the patients were analyzed. Results: Out of 363 patients with long COVID, after excluding 6 patients, 60 patients (16.5%) (55% males, median age of 38 years) complaining of sleep disturbance were compared with 303 patients (83.5%) (43% males, median age of 40 years) without sleep-related symptoms. Although there were no significant differences in clinical backgrounds and severities of COVID-19 between the two groups by the multivariate analysis, the percentage of long COVID patients with sleep disturbance was significantly increased among patients infected in the Omicron-dominant phase. In addition, the prevalence rate of sleep disturbance in patients when infected in the Omicron phase (24.8%) was two-times higher than that in patients infected in the Delta phase (12.8%). Of note, the percentages of patients with sleep disturbance who also complained of general fatigue, headache, concentration loss, anxiety, low-grade fever, and brain fog symptoms were higher than the percentages of patients without sleep disturbance who had the same complaints. Among the types of sleep disturbance, the percentage of patients who complained of loss of sleep induction (75%) was much higher than the percentage of patients with early-awakening sleep disturbance (6.7%), and many of the patients with mid-awakening types of insomnia had brain fog symptoms. Endocrine examinations revealed that long COVID patients with sleep disturbance had significantly higher levels of plasma adrenocorticotropin and lower levels of serum growth hormone, suggesting the presence of hypothalamic–pituitary stress. Conclusion: The prevalence of sleep disturbance has been increasing in long COVID patients infected in the Omicron phase with a certain clinical and endocrine trend.
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- 2022
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5. Isolated unilateral absence of adult pulmonary artery
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Koichiro Yamamoto, Yasuhiro Nakano, and Fumio Otsuka
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collateral artery ,General Medicine ,congenital heart disease ,hemoptysis - Abstract
Isolated unilateral absence of pulmonary artery (UAPA) is a rare congenital malformation. We describe a 26-year-old woman with isolated UAPA who presented with hemoptysis. Since massive hemoptysis may mandate selective embolization of collaterals or surgical treatment, early diagnosis of UAPA is pivotal.
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- 2022
6. Relationships Among Heart Rate, β-Blocker Dosage, and Prognosis in Patients With Coronary Artery Disease in a Real-World Database Using a Multimodal Data Acquisition System
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Yusuke Oba, Tomoyuki Kabutoya, Takahide Kohro, Yasushi Imai, Kazuomi Kario, Hisahiko Sato, Kotaro Nochioka, Masaharu Nakayama, Hideo Fujita, Yoshiko Mizuno, Arihiro Kiyosue, Takamasa Iwai, Yoshihiro Miyamoto, Yasuhiro Nakano, Taishi Nakamura, Kenichi Tsujita, Tetsuya Matoba, and Ryozo Nagai
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General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
The optimal heart rate (HR) and optimal dose of β-blockers (BBs) in patients with coronary artery disease (CAD) have been unclear. We sought to clarify the relationships among HR, BB dose, and prognosis in patients with CAD using a multimodal data acquisition system.Methods and Results: We evaluated the data for 8,744 CAD patients who underwent cardiac catheterization from 6 university hospitals and the National Cerebral and Cardiovascular Center and who were registered using the Clinical Deep Data Accumulation System. Patients were divided into quartile groups based on their HR at discharge: Q1 (HR60 beats/min), Q2 (HR 60-66 beats/min), Q3 (HR 67-74 beats/min), and Q4 (HR ≥75 beats/min). Among patients with acute coronary syndrome (ACS) and patients with chronic coronary syndrome (CCS), those in Q4 (HR ≥75 beats/min) had a significantly greater incidence of major adverse cardiac and cerebral events (MACCE) compared with those in Q1 (ACS patients: hazard ratio 1.65, P=0.001; CCS patients: hazard ratio 1.45, P=0.019). Regarding the use of BBs (n=4,964), low-dose administration was significantly associated with MACCE in the ACS group (hazard ratio 1.41, P=0.012), but not in patients with CCS after adjustment for covariates.HR ≥75 beats/min was associated with worse outcomes in patients with CCS or ACS.
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- 2022
7. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells
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Yoshiaki Soejima, Nahoko Iwata, Nanako Nakayama, Shinichi Hirata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Kohei Oguni, Takahiro Nada, Satoshi Fujisawa, and Fumio Otsuka
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Orexins ,bone morphogenetic protein (BMP) ,clock ,gonadotropin ,orexin ,pituitary ,Organic Chemistry ,Luteinizing Hormone, beta Subunit ,General Medicine ,Catalysis ,Computer Science Applications ,Gonadotropin-Releasing Hormone ,Inorganic Chemistry ,Mice ,Pituitary Gland ,Bone Morphogenetic Proteins ,Follicle Stimulating Hormone, beta Subunit ,Animals ,RNA, Messenger ,Physical and Theoretical Chemistry ,Molecular Biology ,Gonadotropins ,Spectroscopy - Abstract
Orexin plays a key role in the regulation of sleep and wakefulness and in feeding behavior in the central nervous system, but its receptors are expressed in various peripheral tissues including endocrine tissues. In the present study, we elucidated the effects of orexin on pituitary gonadotropin regulation by focusing on the functional involvement of bone morphogenetic proteins (BMPs) and clock genes using mouse gonadotrope LβT2 cells that express orexin type 1 (OX1R) and type 2 (OX2R) receptors. Treatments with orexin A enhanced LHβ and FSHβ mRNA expression in a dose-dependent manner in the absence of GnRH, whereas orexin A in turn suppressed GnRH-induced gonadotropin expression in LβT2 cells. Orexin A downregulated GnRH receptor expression, while GnRH enhanced OX1R and OX2R mRNA expression. Treatments with orexin A as well as GnRH increased the mRNA levels of Bmal1 and Clock, which are oscillational regulators for gonadotropin expression. Of note, treatments with BMP-6 and -15 enhanced OX1R and OX2R mRNA expression with upregulation of clock gene expression. On the other hand, orexin A enhanced BMP receptor signaling of Smad1/5/9 phosphorylation through upregulation of ALK-2/BMPRII among the BMP receptors expressed in LβT2 cells. Collectively, the results indicate that orexin regulates gonadotropin expression via clock gene expression by mutually interacting with GnRH action and the pituitary BMP system in gonadotrope cells.
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- 2022
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8. Manifestation of Headache Affecting Quality of Life in Long COVID Patients
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Kana Fujita, Yuki Otsuka, Naruhiko Sunada, Hiroyuki Honda, Kazuki Tokumasu, Yasuhiro Nakano, Yasue Sakurada, Mikako Obika, Hideharu Hagiya, and Fumio Otsuka
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quality of life (QOL) ,post COVID-19 condition (PCC) ,General Medicine ,COVID-19 aftercare clinic (CAC) ,headache ,long COVID - Abstract
Objectives: The present study aimed to elucidate the characteristics of long COVID patients with headaches. Methods: A single-center retrospective observational study was performed for long COVID outpatients who visited our hospital from 12 February 2021 to 30 November 2022. Results: A total of 482 long COVID patients, after excluding 6, were divided into two groups: the Headache group of patients with complaints of headache (113 patients: 23.4%) and the remaining Headache-free group. Patients in the Headache group were younger (median age: 37 years) than patients in the Headache-free group (42 years), while the ratio of females (56%) in the Headache group was nearly the same as that in the Headache-free group (54%). The proportion of patients in the Headache group who were infected in the Omicron-dominant phase (61%) was larger than the proportions of patients infected in the Delta (24%) and preceding (15%) phases, and that trend was significantly different from the trend in the Headache-free group. The duration before the first visit for long COVID was shorter in the Headache group (71 days) than in the Headache-free group (84 days). The proportions of patients in the Headache group with comorbid symptoms, including general fatigue (76.1%), insomnia (36.3%), dizziness (16.8%), fever (9.7%), and chest pain (5.3%) were larger than the proportions of patients in the Headache-free group, whereas blood biochemical data were not significantly different between the two groups. Interestingly, patients in the Headache group had significant deteriorations of scores indicating depression and scores for quality of life and general fatigue. In multivariate analysis, headache, insomnia, dizziness, lethargy, and numbness were shown to be involved in the quality of life (QOL) of long COVID patients. Conclusions: The manifestation of headaches related to long COVID was found to have a significant impact on social and psychological activities. Alleviation of headaches should be a priority for the effective treatment of long COVID.
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- 2023
9. Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID
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Kazuki Tokumasu, Hiroyuki Honda, Naruhiko Sunada, Yasue Sakurada, Yui Matsuda, Koichiro Yamamoto, Yasuhiro Nakano, Toru Hasegawa, Yukichika Yamamoto, Yuki Otsuka, Hideharu Hagiya, Hitomi Kataoka, Keigo Ueda, and Fumio Otsuka
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musculoskeletal diseases ,Male ,Canada ,Fatigue Syndrome, Chronic ,post-exertional malaise ,general fatigue ,Headache ,virus diseases ,COVID-19 ,General Medicine ,chronic fatigue syndrome ,nervous system diseases ,post COVID-19 condition ,myalgic encephalomyelitis ,Post-Acute COVID-19 Syndrome ,Sleep Initiation and Maintenance Disorders ,Humans ,Female ,long COVID ,myalgic encephalomyelitis/chronic fatigue syndrome ,Retrospective Studies - Abstract
Background and Objectives: COVID-19 can be serious not only in the acute phase but also after the acute phase and some patients develop ME/CFS. There have been few studies on patients with long COVID in whom ME/CFS was diagnosed by physicians based on standardized criteria after examinations and exclusion diagnosis and not based on only subjective symptoms. The purpose of this study was to elucidate the detailed characteristics of ME/CFS in patients with long COVID. Materials and Methods: A retrospective descriptive study was performed for patients who visited a COVID-19 aftercare clinic established in Okayama University Hospital during the period was from February 2021 to April 2022. Results: Clinical data were obtained from medical records for 281 patients, and 279 patients who met the definition of long COVID were included. The overall prevalence rate of ME/CFS diagnosed by three sets of ME/CFS criteria (Fukuda, Canadian and IOM criteria) was 16.8% (48.9% in male and 51.1% in females). The most frequent symptoms in ME/CFS patients were general fatigue and post-exertional malaise (89.4% of the patients), headache (34.0%), insomnia (23.4%), dysosmia (21.3%) and dysgeusia (19.1%). Dizziness, chest pain, insomnia and headache were characteristic symptoms related to ME/CFS. The male to female ratio in ME/CFS patients was equal in the present study, although ME/CFS was generally more common in women in previous studies. Given that patients with ME/CFS had more severe conditions in the acute phase of COVID-19, the severity of the acute infectious state might be involved in the pathophysiology of ME/CFS. Conclusions: The prevalence rate of ME/CFS and the characteristic sequelae in the long COVID condition were revealed in this study.
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- 2022
10. 6. Endocrine and Metabolic Diseases Discovered in General Practice
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Fumio Otsuka, Mikako Obika, Kou Hasegawa, Yasuhiro Nakano, and Kazuki Tokumasu
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General Medicine - Published
- 2021
11. Symptomatic Characteristics of Hypozincemia Detected in Long COVID Patients
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Yui Matsuda, Kazuki Tokumasu, Yuki Otsuka, Naruhiko Sunada, Hiroyuki Honda, Yasue Sakurada, Yasuhiro Nakano, Toru Hasegawa, Mikako Obika, Keigo Ueda, and Fumio Otsuka
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dysosmia ,hypozincemia ,fatigue ,dysgeusia ,General Medicine ,long COVID - Abstract
Objectives: The aim of this study was to determine the characteristics of hypozincemia in long COVID patients. Methods: This study was a single-center retrospective observational study for outpatients who visited the long COVID clinic established in a university hospital during the period from 15 February 2021 to 28 February 2022. Characteristics of patients with a serum zinc concentration lower than 70 μg/dL (10.7 μmol/L) were compared with characteristics of patients with normozincemia. Results: In a total of 194 patients with long COVID after excluding 32 patients, hypozincemia was detected in 43 patients (22.2%) including 16 male patients (37.2%) and 27 female patients (62.8%). Among various parameters including the background characteristics of the patients and medical histories, the patients with hypozincemia were significantly older than the patients with normozincemia (median age: 50 vs. 39 years). A significant negative correlation was found between serum zinc concentrations and age in male patients (R = −0.39; p < 0.01) but not in female patients. In addition, there was no significant correlation between serum zinc levels and inflammatory markers. General fatigue was the most frequent symptom in both male patients with hypozincemia (9 out of 16: 56.3%) and female patients with hypozincemia (8 out of 27: 29.6%). Patients with severe hypozincemia (serum zinc level lower than 60 μg/dL) had major complaints of dysosmia and dysgeusia, which were more frequent complaints than general fatigue. Conclusions: The most frequent symptom in long COVID patients with hypozincemia was general fatigue. Serum zinc levels should be measured in long COVID patients with general fatigue, particularly in male patients.
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- 2023
12. Targeting cellular senescence as a therapeutic approach in non-alcoholic steatohepatitis
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Yasuhiro Nakano and Yoshikazu Johmura
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Hepatology ,General Medicine - Published
- 2023
13. Multiple Deep-seated Dentofacial Abscesses Caused by Multidrug-resistant Viridans Group Streptococci
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Fumio Otsuka, Yuko Hayashi, Kiyoshi Yamada, Shinnosuke Fukushima, Kou Hasegawa, Masahiro Takahara, Hideharu Hagiya, Yuki Mizuta, Kayo Okamoto, and Yasuhiro Nakano
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medicine.medical_specialty ,Fistula ,medicine.medical_treatment ,Case Report ,030204 cardiovascular system & hematology ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,multidrug resistance ,Drug Resistance, Multiple, Bacterial ,Streptococcal Infections ,Internal Medicine ,Medicine ,Humans ,dentofacial abscesses ,viridans ,Aged ,Odontogenic infection ,biology ,business.industry ,Streptococcus ,Osteomyelitis ,osteomyelitis ,Streptococcus oralis ,General Medicine ,Antimicrobial ,medicine.disease ,biology.organism_classification ,Abscess ,Surgery ,Multiple drug resistance ,Diabetes Mellitus, Type 2 ,030211 gastroenterology & hepatology ,Female ,Hemodialysis ,business ,odontogenic infection - Abstract
Odontogenic infections, generally caused by dental caries and periodontal disease, can result in fatal illness. We herein report a 71-year-old Japanese woman with type 2 diabetes and hemodialysis who suffered from multiple dentofacial abscesses mainly caused by multidrug-resistant Streptococcus oralis. She complained of pain and swelling of her face, with an extraoral fistula from the left cheek. Following 3 surgical debridement procedures and partial mandibulectomy, in addition to 12 weeks of antimicrobial therapy, the multiple dentofacial abscesses were ameliorated. A combination of surgical and antimicrobial treatments following an early diagnosis is essential for reducing further complications.
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- 2020
14. Coronary Spastic Angina Induced by Adrenal Insufficiency
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Yuki Otsuka, Yasuhiro Nakano, Miho Yasuda, Fumio Otsuka, Ko Harada, and Kou Hasegawa
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Male ,medicine.medical_specialty ,Hydrocortisone ,medicine.drug_class ,Hormone Replacement Therapy ,Case Report ,030204 cardiovascular system & hematology ,Primary Adrenal Insufficiency ,Angina Pectoris ,Angina ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,coronary vasospasm ,Internal Medicine ,medicine ,Adrenal insufficiency ,Humans ,Glucocorticoids ,Dexamethasone ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,steroid replacement ,Circadian Rhythm ,Coronary vasospasm ,Cardiology ,Corticosteroid ,030211 gastroenterology & hepatology ,Complication ,business ,adrenal insufficiency ,Glucocorticoid ,medicine.drug - Abstract
Adrenal insufficiency patients are treated with glucocorticoid replacement therapy. However, mimicking the in vivo circadian rhythm of cortisol levels is challenging, and suboptimal replacement increases the risk of mortality from cardiovascular disease. We herein report a case of coronary spastic angina (CSA) with simultaneous low early-morning serum cortisol levels in a patient undergoing corticosteroid replacement therapy for primary adrenal insufficiency. Steroid therapy is reportedly effective for refractory angina, but underlying adrenal deficiency has never been revealed. Our case intimates the probable risk of CSA as a complication of relative adrenal insufficiency and highlights the effectiveness of dexamethasone in these patients.
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- 2020
15. Takayasu Arteritis Mimicking Phlegmon
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Yuki, Taira, Yasuhiro, Nakano, Yoshihisa, Hanayama, and Fumio, Otsuka
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Internal Medicine ,General Medicine - Published
- 2023
16. Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells
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Takahiro Nada, Yasuhiro Nakano, Fumio Otsuka, Yoshiaki Soejima, Atsuhito Suyama, Nahoko Iwata, and Koichiro Yamamoto
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endocrine system ,QH301-705.5 ,medicine.drug_class ,MAP Kinase Signaling System ,CLOCK Proteins ,Stimulation ,Gonadotrophs ,Gonadotropic cell ,Bone morphogenetic protein ,Catalysis ,Article ,Cell Line ,Inorganic Chemistry ,Gonadotropin-Releasing Hormone ,Mice ,Clock ,medicine ,Animals ,mitogen-activated protein kinase (MAPK) ,RNA, Messenger ,Biology (General) ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Spectroscopy ,Chemistry ,bone morphogenetic protein (BMP) ,Organic Chemistry ,ARNTL Transcription Factors ,luteinizing hormone and mitogen-activated protein kinase (MAPK) ,General Medicine ,Period Circadian Proteins ,Luteinizing Hormone ,Computer Science Applications ,Gonadotropin secretion ,Cell biology ,CLOCK ,PER2 ,Cryptochromes ,Gene Expression Regulation ,Bone Morphogenetic Proteins ,Gonadotropin ,Mitogen-Activated Protein Kinases ,Luteinizing hormone ,hormones, hormone substitutes, and hormone antagonists ,gonadotropins - Abstract
Roles of Clock genes and the bone morphogenetic protein (BMP) system in the regulation of gonadotropin secretion by gonadotropin-releasing hormone (GnRH) were investigated using mouse gonadotropin L beta T2 cells. It was found that luteinizing hormone (LH)beta mRNA expression level in L beta T2 cells changed gradually over time, with LH beta expression being suppressed in the early phase up to 12 h and then elevated in the late phase 24 h after GnRH stimulation. In addition, the mRNA expression levels of Clock genes, including Bmal1, Clock, Per2, and Cry1, also showed temporal changes mimicking the pattern of LH beta expression in the presence and absence of GnRH. Notably, the expression levels of Bmal1 and Clock showed strong positive correlations with LH beta mRNA expression levels. Moreover, a functional link of the ERK signaling of mitogen-activated protein kinases (MAPKs) in the suppression of LH beta mRNA expression, as well as Bmal1 and Clock mRNA expression by GnRH at the early phase, was revealed. Inhibition of Bmal1 and Clock expression using siRNA was involved in the reduction in LH beta mRNA levels in the late phase 24 h after GnRH stimulation. Furthermore, in the presence of BMP-6 and -7, late-phase Bmal1 and LH beta mRNA expression after GnRH stimulation was significantly attenuated. Collectively, the results indicated that LH expression in gonadotrope cells exhibits Bmal1/Clock-dependent fluctuations under the influence of GnRH and that the fluctuations are regulated by ERK and BMPs in the early and late stages, respectively, in a phase-dependent manner after GnRH stimulation.
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- 2021
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17. Subcutaneous edema as rare complication of abdominal paracentesis
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Yuki Otsuka, Hirokazu Nagaoka, Hiroyuki Sakae, Kou Hasegawa, Fumio Otsuka, and Yasuhiro Nakano
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Medicine (General) ,medicine.medical_specialty ,medicine.diagnostic_test ,Potential risk ,business.industry ,Abdominal paracentesis ,complication ,General Medicine ,Surgery ,ascites ,R5-920 ,Effusion ,Clinical Images ,Clinical Image ,Ascites ,medicine ,Paracentesis ,Medicine ,image ,medicine.symptom ,Subcutaneous edema ,Complication ,business ,abdominal paracentesis - Abstract
Although ascites leakage to the skin is the most frequent complication after abdominal paracentesis, leakage to the subcutaneous space has not been reported. Here, we report a subcutaneous effusion after paracentesis suggesting ascites leakage. We should be aware of this rare complication due to the potential risk of dissemination.
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- 2021
18. Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan
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Yasuhiro Nakano, Yuki Otsuka, Hiroyuki Honda, Naruhiko Sunada, Kazuki Tokumasu, Yasue Sakurada, Yui Matsuda, Toru Hasegawa, Kanako Ochi, Hideharu Hagiya, Hitomi Kataoka, Keigo Ueda, and Fumio Otsuka
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Japan ,SARS-CoV-2 ,dysosmia ,myalgic encephalomyelitis/chronic fatigue syndrome ,Humans ,COVID-19 ,and post COVID-19 condition ,dysgeusia ,Omicron variant ,General Medicine ,Fatigue - Abstract
Background and Objectives: Changes in post COVID-19 condition (PCC) characteristics caused by viral variants have yet to be clarified. We aimed to characterize the differences between clinical backgrounds and manifestations in long COVID patients who were infected with the Delta variant and those who were infected with the Omicron variants. Materials and Methods: This study was a single-center retrospective observational study for patients who visited our COVID-19 aftercare outpatient clinic (CAC) established in Okayama University Hospital (Japan) during the period from 15 February 2021 to 15 July 2022. We classified the onset of COVID-19 in the patients into three groups, the preceding, Delta-dominant, and Omicron-dominant periods, based on the prevalent periods of the variants in our prefecture. Results: In a total of 353 patients, after excluding 8 patients, 110, 130, and 113 patients were classified into the preceding, Delta-dominant, and Omicron-dominant periods, respectively. Patients infected in the Omicron-dominant period had significantly fewer hospitalizations, milder illnesses, more vaccinations and earlier visit to the CAC than did patients infected in the Delta-dominant period. Patients infected in the Omicron-dominant period had significantly lower frequencies of dysosmia (12% vs. 45%, ** p < 0.01), dysgeusia (14% vs. 40%, ** p < 0.01) and hair loss (7% vs. 28%, ** p < 0.01) but had higher frequencies of fatigue (65% vs. 50%, * p < 0.05), insomnia (26% vs. 13%, * p < 0.05) and cough (20% vs. 7%, ** p < 0.01) than did patients infected in the Delta-dominant period. Conclusions: The transitional changes in long COVID symptoms caused by the two variants were characterized.
- Published
- 2022
19. Barium appendicitis
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Daisuke Omura, Naoko Yunoki, Yuki Otsuka, Yasuhiro Nakano, Hideharu Hagiya, and Fumio Otsuka
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appendicitis ,Medicine (General) ,R5-920 ,Clinical Images ,Clinical Image ,digestive, oral, and skin physiology ,otorhinolaryngologic diseases ,Medicine ,barium ,General Medicine ,digestive system diseases - Abstract
We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication., We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication. (41 words).
- Published
- 2021
20. Application of Kampo Medicines for Treatment of General Fatigue Due to Long COVID
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Kazuki Tokumasu, Keigo Ueda, Hiroyuki Honda, Naruhiko Sunada, Yasue Sakurada, Yui Matsuda, Yasuhiro Nakano, Toru Hasegawa, Yuki Otsuka, Mikako Obika, Hideharu Hagiya, Hitomi Kataoka, and Fumio Otsuka
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Plants, Medicinal ,general fatigue ,COVID-19 ,General Medicine ,COVID-19 Drug Treatment ,Post-Acute COVID-19 Syndrome ,Kampo medicine ,herbal medicine ,Humans ,long COVID ,Medicine, Kampo ,Fatigue ,Retrospective Studies - Abstract
Evidence regarding treatment for the acute phase of COVID-19 has been accumulating, but specific treatment for long COVID/post-COVID-19 condition has not yet been established. Treatment with herbal medicine might be one treatment option for long COVID, but there has been little research on the effectiveness of herbal medicine for long COVID. The aim of this study was to clarify the prescription patterns of Kampo medicines, which are herbal medicines that originated in China and were developed in Japan, for the treatment of general fatigue due to long COVID. A retrospective descriptive study was performed for patients who visited a COVID-19 aftercare clinic established in Okayama University Hospital during the period from Feb 2021 to Dec 2021 with a focus on symptoms accompanying general fatigue and prescriptions of Kampo medicine. Among the clinical data obtained from medical records of 195 patients, clinical data for 102 patients with general fatigue and accompanying symptoms were analyzed. The patients had various symptoms, and the most frequent symptoms accompanying general fatigue were dysosmia, dysgeusia, headache, insomnia, dyspnea, and hair loss. Prescriptions of Kampo medicine accounted for 24.1% of the total prescriptions (n = 609). The most frequently prescribed Kampo medicine was hochuekkito (71.6%) and other prescribed Kampo medicines were tokishakuyakusan, ryokeijutsukanto, juzentaihoto, hangekobokuto, kakkonto, ninjin’yoeito, goreisan, rikkunshito, and keishibukuryogan. Since the pathophysiology of general fatigue after an infectious disease is, in general, considered a qi deficiency in Kampo medicine, treatments with such compensation agents can be the major prescription as a complement for the qi. In conclusion, Kampo medicine can be one of the main pharmacological treatments for long COVID accompanying general fatigue.
- Published
- 2022
21. Clival Osteomyelitis with Cavernous Sinus Thrombosis Due to Fusobacterium nucleatum and Campylobacter rectus Induced by Tooth Extraction
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Yasuhiro Nakano, Masaya Iwamuro, Fumio Otsuka, Shigeru Horiguchi, Yosuke Sazumi, Kazuki Ocho, Tomo Michitani, and Kosuke Oka
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medicine.medical_specialty ,Cavernous sinus thrombosis ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Clivus ,Internal Medicine ,medicine ,030212 general & internal medicine ,biology ,medicine.diagnostic_test ,business.industry ,Osteomyelitis ,Campylobacter rectus ,Aseptic meningitis ,Magnetic resonance imaging ,General Medicine ,biology.organism_classification ,medicine.disease ,Surgery ,stomatognathic diseases ,medicine.anatomical_structure ,Respiratory failure ,Fusobacterium nucleatum ,business ,030217 neurology & neurosurgery - Abstract
A 70-year-old woman who had suffered from aseptic meningitis complained of chronic headache after dental treatment including tooth extraction. She developed a fever and respiratory failure. Based on chest computed tomography and head magnetic resonance imaging (MRI), she was diagnosed with osteomyelitis in the clivus accompanying moderate pituitary involvement, cavernous sinus thrombosis and septic pulmonary embolism. Both of the causal bacteria, Fusobacterium nucleatum and Campylobacter rectus, were isolated from her blood. Dual infection leading to clival osteomyelitis and cavernous sinus thrombosis has not been reported. It is important to perform enhanced MRI and blood culture for patients with chronic headache related to dental treatment.
- Published
- 2018
22. Acute encephalopathy associated with severe fever with thrombocytopaenia syndrome
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Hideharu Hagiya, Hiroyuki Honda, Manami Fujita, and Yasuhiro Nakano
- Subjects
0301 basic medicine ,Involuntary movement ,Slurred speech ,Pediatrics ,medicine.medical_specialty ,Brain Diseases ,Severe Fever with Thrombocytopenia Syndrome ,Images In… ,business.industry ,Acute encephalopathy ,Video Recording ,General Medicine ,Anorexia ,030105 genetics & heredity ,03 medical and health sciences ,0302 clinical medicine ,Tremor ,Medicine ,Humans ,Female ,medicine.symptom ,business ,human activities ,030217 neurology & neurosurgery ,Aged - Abstract
In July 2020, a 72-year-old Japanese woman with hypertension and dyslipidaemia presented with a 5-day history of fatigue and anorexia, followed by fever, slurred speech and involuntary movement of the upper limbs. She had not travelled abroad recently. She lived at the edge of a copse located in
- Published
- 2020
23. Late-Onset Hypogonadism in a Male Patient with Long COVID Diagnosed by Exclusion of ME/CFS
- Author
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Yoshiaki Soejima, Yuki Otsuka, Kazuki Tokumasu, Yasuhiro Nakano, Ko Harada, Kenta Nakamoto, Naruhiko Sunada, Yasue Sakurada, Kou Hasegawa, Hideharu Hagiya, Keigo Ueda, and Fumio Otsuka
- Subjects
free testosterone ,general fatigue ,General Medicine ,long COVID ,post-COVID condition ,late-onset hypogonadism - Abstract
After the acute phase of COVID-19, some patients have been reported to have persistent symptoms including general fatigue. We have established a COVID-19 aftercare clinic (CAC) to provide care for an increasing number of these patients. Here, we report the case of a 36-year-old man who developed post-COVID fatigue after acute infection with SARS-CoV-2. In the acute phase of COVID-19, the patient’s fever resolved within four days; however, general fatigue persisted for three months, and he visited our CAC 99 days after the initial infection. Examination revealed a high Aging Male’s Symptoms (AMS) score of 44 and low free testosterone (FT) level of 5.5 pg/mL, which meet the Japanese criteria of late-onset hypogonadism (LOH) syndrome. Imaging studies revealed an atrophic pituitary in addition to fatty liver and low bone mineral density. Anterior pituitary function tests showed a low follicle-stimulating hormonelevel and delayed reaction of luteinizing hormone (LH) after gonadotropin-releasing hormone (GnRH) stimulation, indicating the possibility of hypothalamic hypogonadism in addition to primary hypogonadism seen in patients with post-COVID-19 conditions. After the initiation of Japanese traditional medicine (Kampo medicine: hochuekkito followed by juzentaihoto), the patient’s symptoms as well as his AMS score and serum FT level were noticeably improved. Furthermore, follow-up tests of GnRH stimulation revealed improvements in LH responsiveness. Although many patients have been reported to meet the criteria of ME/CFS such as our case, we emphasize the possibility of other underlying pathologies including LOH syndrome. In conclusion, LOH syndrome should be considered a cause of general fatigue in patients with post-COVID-19 conditions and herbal treatment might be effective for long COVID symptoms due to LOH (264 words).
- Published
- 2022
24. Detection of Male Hypogonadism in Patients with Post COVID-19 Condition
- Author
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Yukichika Yamamoto, Yuki Otsuka, Naruhiko Sunada, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Hideharu Hagiya, Yoshihisa Hanayama, and Fumio Otsuka
- Subjects
testosterone ,hypogonadism ,LOH syndrome ,fatigue ,General Medicine ,long COVID - Abstract
The pathogenesis and prognosis of post COVID-19 condition have remained unclear. We set up an outpatient clinic specializing in long COVID in February 2021 and we have been investigating post COVID-19 condition. Based on the results of our earlier study showing that “general fatigue” mimicking myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the most common symptom in long COVID patients, a retrospective analysis was performed for 39 male patients in whom serum free testosterone (FT) levels were measured out of 61 male patients who visited our clinic. We analyzed the medical records of the patients’ backgrounds, symptoms and laboratory results. Among the 39 patients, 19 patients (48.7%) met the criteria for late-onset hypogonadism (LOH; FT < 8.5 pg/mL: LOH group) and 14 patients were under 50 years of age. A weak negative correlation was found between age and serum FT level (r = −0.301, p = 0.0624). Symptoms including general fatigue, anxiety, cough and hair loss were more frequent in the LOH group than in the non-LOH group (FT ≥ 8.5 pg/mL). Among various laboratory parameters, blood hemoglobin level was slightly, but significantly, lower in the LOH group. Serum level of FT was positively correlated with the levels of blood hemoglobin and serum total protein and albumin in the total population, whereas these interrelationships were blurred in the LOH group. Collectively, the results indicate that the incidence of LOH is relatively high in male patients, even young male patients, with post COVID-19 and that serum FT measurement is useful for revealing occult LOH status in patients with long COVID.
- Published
- 2022
25. Serial Changes of Long COVID Symptoms and Clinical Utility of Serum Antibody Titers for Evaluation of Long COVID
- Author
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Yasue Sakurada, Naruhiko Sunada, Hiroyuki Honda, Kazuki Tokumasu, Yuki Otsuka, Yasuhiro Nakano, Yoshihisa Hanayama, Masanori Furukawa, Hideharu Hagiya, and Fumio Otsuka
- Subjects
Anti-SARS-CoV2 antibody ,dysosmia ,general fatigue ,dysgeusia ,General Medicine ,long COVID - Abstract
Background: Various symptoms persist even after the acute symptoms in about one third of patients with COVID-19. In February 2021, we established an outpatient clinic in a university hospital for patients with long COVID and started medical treatment for sequelae that persisted one month or more after infection. Methods: To determine the key factors that affect the onset and clinical course of sequelae, a retrospective analysis was performed at Okayama University Hospital (Japan) between February and July 2021. We focused on changes in the numbers of symptoms and the background of the patients during a three-month period from the first outpatient visit. We also examined the relationship with SARS-CoV-2 antibody titers. Results: Information was obtained from medical records for 65 patients. The symptoms of sequelae were diverse, with more than 20 types. The most frequent symptoms were general malaise, dysosmia, dysgeusia, sleeplessness, and headache. These symptoms improved in about 60% of the patients after 3 months. Patients who required hospitalization and had a poor condition in the acute phase and patients who received oxygen/dexamethasone therapy had higher antibody titers at the time of consultation. Patients with antibody titers ≥200 U/mL showed significantly fewer improvements in long COVID symptoms in 1 month, but they showed improvements at 3 months after the first visit. Conclusion: Long COVID symptoms were improved at 3 months after the initial visit in more than half of the patients. Serum antibody titers were higher in patients who experienced a severe acute phase, but the serum antibody titers did not seem to be directly related to the long-term persistence of long COVID symptoms.
- Published
- 2022
26. Dysphagia Induced by Acromegalic Arthropathy
- Author
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Manami Fujita, Fumio Otsuka, Yasuhiro Nakano, and Hiroyuki Sakae
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Acromegalic Arthropathy ,General Medicine ,medicine.disease ,Dysphagia ,Dermatology ,Pictures in Clinical Medicine ,osteophyte ,Arthropathy ,Acromegaly ,Internal Medicine ,medicine ,Humans ,medicine.symptom ,Joint Diseases ,business ,Deglutition Disorders ,arthropathy - Published
- 2020
27. X-linked Hypophosphatemia (XLH) Mimicking Rheumatic Disease
- Author
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Fumio Otsuka, Ryosuke Takase, Yasuhiro Nakano, and Kosei Hasegawa
- Subjects
medicine.medical_specialty ,and X-linked hypophosphatemia (XLH) ,business.industry ,MEDLINE ,Rheumatic disease ,General Medicine ,hypophosphatemic rickets and osteomalacia ,X-linked hypophosphatemia ,medicine.disease ,Pictures in Clinical Medicine ,Internal medicine ,fibroblast growth factor (FGF)-23 ,Internal Medicine ,Medicine ,business - Published
- 2020
28. Simultaneous hot and cold thyroid nodules: Which is malignant?
- Author
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Yasuhiro Nakano, Fumio Otsuka, Yuki Otsuka, Daisuke Omura, Takayuki Iwamoto, and Ruiko Hayashi
- Subjects
Thyroid nodules ,medicine.medical_specialty ,endocrine system ,Thyroid papillary cancer ,endocrine system diseases ,Risk of malignancy ,lcsh:Medicine ,toxic multinodular goiter ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,thyroid papillary cancer ,Clinical Images ,Multinodular goiter ,Medicine ,hyperthyroidism ,In patient ,lcsh:R5-920 ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Dermatology ,030220 oncology & carcinogenesis ,Clinical Image ,Radiology ,lcsh:Medicine (General) ,business ,autonomous functioning thyroid nodule - Abstract
Physicians should be aware of the risk of malignancy in patients with toxic multinodular goiter. Radionuclide scan cannot be used to predict the malignant potential of thyroid nodules. A comprehensive evaluation of imaging studies is needed.
- Published
- 2021
29. Hypothalamic Mass Detected in Langerhans Cell Histiocytosis
- Author
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Yasuhiro Nakano, Shin Morizane, Fumio Otsuka, and Ryosuke Takase
- Subjects
Langerhans cell histiocytosis (LCH) ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General Medicine ,Hypopituitarism ,medicine.disease ,hypopituitarism and skin biopsy ,Histiocytosis, Langerhans-Cell ,Pictures in Clinical Medicine ,Langerhans cell histiocytosis ,diabetes insipidus ,Diabetes insipidus ,Skin biopsy ,Internal Medicine ,Humans ,Medicine ,Nervous System Diseases ,Hypothalamic mass ,FDG-PET ,business - Published
- 2021
30. Hepatic encephalopathy due to extrahepatic portosystemic shunt
- Author
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Yosuke Sazumi, Yuki Otsuka, Yoshito Nishimura, Hiroyuki Sakae, Fumio Otsuka, Yasuhiro Nakano, and Yuki Mizuta
- Subjects
medicine.medical_specialty ,lcsh:R5-920 ,portal hypertension and altered mental status ,business.industry ,lcsh:R ,hepatic encephalopathy ,Hemodynamics ,lcsh:Medicine ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,030220 oncology & carcinogenesis ,Internal medicine ,Clinical Image ,medicine ,Cardiology ,Treatment strategy ,Portosystemic shunt ,extrahepatic portosystemic shunt ,business ,lcsh:Medicine (General) ,Hepatic encephalopathy - Abstract
Clinicians should recognize extrahepatic portosystemic shunt as a cause of refractory or intermittent hepatic encephalopathy. Treatment strategies should be individualized according to patients' anatomic and hemodynamic status.
- Published
- 2020
31. Unexpected, But Reasonable Association Between Anderson-Fabry Disease and Coronary Vasospasm
- Author
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Yasuhiro Nakano, Tetsuya Matoba, and Hiroyuki Tsutsui
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Coronary Vasospasm ,General Medicine ,medicine.disease ,Fabry disease ,Angina Pectoris ,Anderson-Fabry Disease ,Muscle Spasticity ,Internal medicine ,Coronary vasospasm ,medicine ,Cardiology ,Prevalence ,Fabry Disease ,Humans ,Cardiology and Cardiovascular Medicine ,business - Published
- 2019
32. Symptomatic Adrenal Myelolipoma
- Author
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Daisuke Omura, Ryosuke Takase, Fumio Otsuka, and Yasuhiro Nakano
- Subjects
medicine.medical_specialty ,Pictures in Clinical Medicine ,Adrenal myelolipoma ,business.industry ,Adrenalectomy ,medicine.medical_treatment ,Internal Medicine ,medicine ,adrenalectomy ,General Medicine ,Radiology ,business ,adrenal myelolipoma - Published
- 2018
33. Auricle Pain Due to Tophi
- Author
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Fumio Otsuka and Yasuhiro Nakano
- Subjects
Male ,Auricle ,medicine.medical_specialty ,Arthritis, Gouty ,business.industry ,pinna tophi and uric acid ,Pain ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Gout Suppressants ,Uric Acid ,Gout ,Febuxostat ,Pictures in Clinical Medicine ,gout ,medicine.anatomical_structure ,Internal Medicine ,Humans ,Medicine ,business ,Ear Auricle ,medicine.drug - Published
- 2019
34. The Effect of Low Frame Rate Fluoroscopy on the X-ray Dose during Coronary Intervention
- Author
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Yasuhiro Nakano and Kenji Sadamatsu
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Radiography ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Radiation Dosage ,Radiography, Interventional ,Coronary artery disease ,03 medical and health sciences ,Kerma ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Japan ,Internal Medicine ,medicine ,Fluoroscopy ,Humans ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,Retrospective cohort study ,General Medicine ,Middle Aged ,Frame rate ,medicine.disease ,Angiography ,Female ,Radiology ,business - Abstract
Objective The aim of this study was to investigate whether the use of low frame rate fluoroscopy at 7.5 frames per second during coronary intervention could reduce radiation exposure in Japanese patients. Methods From December 10, 2014 to March 20, 2015, 84 consecutive patients with coronary artery disease who underwent coronary intervention in our institution were retrospectively collected and then divided into two groups: the LR group (fluoroscopy at 7.5 frames per second) and the OR group (fluoroscopy at 15 frames per second), according to the frame rate of fluoroscopy that was used in their treatment. Results There were no differences in the patient backgrounds or the procedural characteristics of the two groups. Although there were no differences in the contrast volume or fluoroscopy time, the total air kerma at the interventional reference point, which is used to monitor the patient's radiation dose, was significantly lower in the LR group than in the OR group (701.4±427.9 vs. 936.8±623.9 mGy, p=0.02). Conclusion Low frame rate fluoroscopy at 7.5 frames per second is safe and feasible for use during coronary interventions and an easy and useful strategy for reducing the radiation to which patients are exposed during coronary intervention.
- Published
- 2016
35. Risk of additional pancreatic cancer in patients with branch duct intraductal papillary-mucinous neoplasm
- Author
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Manabu Osanai, Yasuhiro Nakano, Kazuya Koizumi, Takeshi Obara, Yutaka Kohgo, Satoshi Tanno, and Yusuke Mizukami
- Subjects
medicine.medical_specialty ,endocrine system diseases ,Intraductal papillary mucinous neoplasm ,business.industry ,Gastroenterology ,General Medicine ,Hepatology ,medicine.disease ,Branch Duct ,medicine.anatomical_structure ,Surgical oncology ,Internal medicine ,Pancreatic cancer ,medicine ,Field cancerization ,Risk factor ,business ,Pancreas - Abstract
Branch duct intraductal papillary-mucinous neoplasms of the pancreas (BD-IPMN) are being diagnosed with increasing frequency. Although BD-IPMN outcomes are generally good, pancreatic ductal adenocarcinoma (PDA) is found distant from the original BD-IPMN in about 3.3-9.2% of cases. These reports raise the question of whether a possible association exists between BD-IPMN and PDA. Recent findings from follow-up studies suggest that pancreases with BD-IPMNs have a high risk of developing additional pancreatic cancer, with standardized incidence ratios (SIRs) of 15.8- to 26-fold. These studies suggest that special attention should be paid to BD-IPMN patients who are ≥70 years. Furthermore, molecular evidence supports the hypothesis that field cancerization causing multiple primary neoplastic lesions exists in pancreases harboring IPMNs. Although more extensive studies are required to clarify the magnitude of this increased risk, clinicians should pay close attention to the development of PDA in patients with BD-IPMN, as well as to changes in BD-IPMN lesions.
- Published
- 2009
36. Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
- Author
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Kazumasa Nakamura, Mikihiro Fujiya, Toshikatsu Okumura, Tomoya Nishikawa, Nobuyuki Yanagawa, Atsuo Maemoto, Yutaka Kohgo, Yoshiaki Sugiyama, Toshifumi Ashida, Junpei Sasajima, Madoka Yamazaki, Yasuhiro Nakano, Kazuya Sato, Masaaki, Yusuke Mizukami, Toru Kono, Hidenori Karasaki, Satoshi Tanno, and Daniel C. Chung
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Umbilical Veins ,Cancer Research ,Angiogenesis ,Fluorescent Antibody Technique ,chemistry.chemical_compound ,Sonic hedgehog ,Cells, Cultured ,Neovascularization, Pathologic ,Reverse Transcriptase Polymerase Chain Reaction ,Stem Cells ,Veratrum Alkaloids ,学位授与年月日:平成20年9月30日 ,Dermis ,General Medicine ,Hedgehog signaling pathway ,Patched-1 Receptor ,Vascular endothelial growth factor ,Endothelial stem cell ,Vascular endothelial growth factor A ,Oncology ,embryonic structures ,cardiovascular system ,Female ,Human umbilical vein endothelial cell ,Carcinoma, Pancreatic Ductal ,Signal Transduction ,Patched Receptors ,medicine.medical_specialty ,animal structures ,Cyclopamine ,Blotting, Western ,Receptors, Cell Surface ,Biology ,Internal medicine ,Angiopoietin-1 ,medicine ,Humans ,Hedgehog Proteins ,RNA, Messenger ,Aged ,Chemokine CXCL12 ,Pancreatic Neoplasms ,Endocrinology ,chemistry ,旭川医科大学:博士(医学)(乙第412号) ,Cancer research ,biology.protein ,Endothelium, Vascular - Abstract
Hedgehog signaling is important in the pathogenesis of pancreatic cancer. Several recent observations suggest the involvement of sonic hedgehog (SHH) in postnatal neovascularization. We identified a novel role for SHH in tumor-associated angiogenesis in pancreatic cancer. Immunohistochemical analysis revealed that patched homolog 1 (PTCH1), both a receptor for and transcriptional target of hedgehog signaling, was expressed in a small fraction of endothelial cells within pancreatic cancer, but not in normal pancreatic tissue. When endothelial progenitor cells (EPC) isolated from human peripheral blood were cultured with supernatant from SHH-transfected 293 cells or pancreatic cancer cells, mRNA levels of vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 and angiopoietin-1 were significantly increased, whereas no such induction was observed in human umbilical vein endothelial cell (HUVEC) and human dermal microvascular endothelial cell (HMVEC). HUVEC tube formation was stimulated when cocultured with EPC, and preconditioning EPC with supernatant from KP-1 N pancreatic cancer cells highly expressing SHH significantly enhanced the effect. The effect was partially attenuated by specific inhibition of SHH with cyclopamine or a neutralizing antibody. These findings suggest that tumor-derived SHH can induce angiogenesis, and this is mediated by its effects on EPC specifically. Targeting SHH would be a novel therapeutic approach that can inhibit not only proliferation of cancer cells but also EPC-mediated angiogenesis.
- Published
- 2008
37. A Phase I Study of Oral Uracil-Tegafur Prior to Weekly Intravenous Gemcitabine in Patients with Advanced Pancreatic Cancer
- Author
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Nobuyuki Yanagawa, Satoshi Tanno, Yasuhiro Nakano, Kazuya Koizumi, Yusuke Mizukami, Yutaka Kohgo, Toshikatsu Okumura, Manabu Osanai, Tsutomu Izawa, Atsuya Habiro, and Tsuneshi Fujii
- Subjects
Male ,medicine.medical_specialty ,Pancreatic disease ,Maximum Tolerated Dose ,medicine.drug_class ,Administration, Oral ,Deoxycytidine ,Gastroenterology ,Tegafur ,Antimetabolite ,Drug Administration Schedule ,Oral administration ,Internal medicine ,Pancreatic cancer ,Antineoplastic Combined Chemotherapy Protocols ,Drug Discovery ,Humans ,Medicine ,Prodrugs ,Pharmacology (medical) ,Uracil ,Aged ,Pharmacology ,Leukopenia ,Dose-Response Relationship, Drug ,business.industry ,Combination chemotherapy ,General Medicine ,Middle Aged ,medicine.disease ,Gemcitabine ,Surgery ,Pancreatic Neoplasms ,Infectious Diseases ,Oncology ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Background: Gemcitabine is widely accepted as the first-line agent for advanced pancreatic cancer. The antitumor cell activity of gemcitabine is higher when administered after 5-fluorouracil (5-FU) rather than before 5-FU in an in vitro study. The present study was conducted to define the maximum tolerated dose and dose-limiting toxicity associated with an oral fluoropyrimidine prodrug that combines uracil and tegafur (UFT), given prior to weekly intravenous gemcitabine in patients with advanced pancreatic cancer. Methods: Over a 21-day cycle, gemcitabine was given intravenously over 30 min on days 8 and 15, while UFT was given orally from days 1 to 14. The dose of UFT used was 400 mg per day, given as two doses. The dose of gemcitabine was escalated in a stepwise fashion from 800 (level 1, n = 3) to 900 mg/m2 (level 2, n = 6) and then to 1,000 mg/m2 (level 3, n = 3), such that totally 12 patients received the combination chemotherapy. Results: During the first cycle, grade 3 leukopenia was observed in 2 patients at dose level 1. Only 1 patient treated at dose level 2 experienced dose-limiting toxicity (grade 3 elevated transaminase), including additional patients treated at this dose level. No grade 3/4 toxicities occurred in patients treated at dose level 3. A significant response was observed in 1 out of 12 patients (8.3%). Seven patients (58.3%) had stable disease, while 4 patients (33.3%) showed disease progression. Conclusions: The combination chemotherapy of oral UFT and gemcitabine was convenient, well tolerated and may benefit patients with advanced pancreatic cancer. Doses recommended for further study of this schedule are gemcitabine 1,000 mg/m2 and UFT 400 mg/day.
- Published
- 2006
38. Development of a Guinea Pig Model of Chronic Asthma with Markedly Thickened Airway Walls: Two Studies Using This Animal Model
- Author
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Hironori Sagara, Takako Hiyama, Masao Toda, Takeshi Fukuda, Yasuhiro Nakano, and Minoru Yoshida
- Subjects
Bronchus ,Pathology ,medicine.medical_specialty ,Allergy ,business.industry ,Immunology ,Respiratory disease ,General Medicine ,medicine.disease ,Pathogenesis ,Guinea pig ,medicine.anatomical_structure ,medicine ,Immunology and Allergy ,Airway ,business ,Asthma ,Respiratory tract - Published
- 2001
39. ChemInform Abstract: Catalytic Reduction of Diphenylacetylene by Zinc over Palladium-Carbon Using Viologens as Electron Mediators
- Author
-
Kimiho Yamada, Hideto Shosenji, and Yasuhiro Nakano
- Subjects
inorganic chemicals ,chemistry.chemical_element ,Selective catalytic reduction ,General Medicine ,Zinc ,Ion ,Catalysis ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Bibenzyl ,Diphenylacetylene ,Carbon ,Palladium - Abstract
Diphenylacetylene was reduced over palladium–carbon in methanol–water mixture in presence of zinc using N,N′-dialkyl-4,4′-bipyridinium ions (viologens) as mediators giving cis-stilbene as the major product and bibenzyl as the minor one. The reaction involved the direct contact of zinc with the catalyst.
- Published
- 1988
Catalog
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