1. The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry
- Author
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Lei Wang, Fangyuan Chen, Qingyin Wang, Zhiyi Shi, Jilin Zhang, Gao Lei, Sudong Mo, Yongsheng Tian, Hui Li, Changwei Shao, Zhiyuan Xie, Baolong Bao, Wenjun Chen, Xihong Li, Kristin Hamre, Yangzhen Li, Songlin Chen, Wenhui Li, Zhongdian Dong, Qiulin Yao, Takashi Sakamoto, Xiaodong Jia, Deborah M. Power, Juan Xu, Alexander M. Schreiber, Manfred Schartl, Junwei Gai, Fen Wei, Bo Li, Qiong Shi, Xinye Chen, Yunji Xiu, Guillermo Ortí, Na Wang, Guojie Zhang, and Wenteng Xu
- Subjects
Fish Proteins ,0301 basic medicine ,Thyroid Hormones ,Evolution ,media_common.quotation_subject ,Retinoic acid ,Tretinoin ,Genomics ,Flounder ,Transcriptome ,03 medical and health sciences ,chemistry.chemical_compound ,Flatfish ,ウイルス耐病性責任遺伝子を用いた天然魚における遺伝子選抜育種技術の開発 ,Morphogenesis ,Genetics ,Animals ,Metamorphosis ,media_common ,Comparative genomics ,Genome ,biology ,Pigmentation ,Metamorphosis, Biological ,04 agricultural and veterinary sciences ,科学研究費研究成果 ,biology.organism_classification ,Biological Evolution ,Gene expression profiling ,Hippoglossus L. larvae ,030104 developmental biology ,Genes ,chemistry ,Evolutionary biology ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Craniofacial asymmetry ,Thyroid-hormone ,Product ,Receptor ,Visual phototransduction - Abstract
Flatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation(1-5). The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish and transcriptomic analyses during metamorphosis point to a role for thyroid hormone and retinoic acid signaling, as well as phototransduction pathways. We demonstrate that retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones, in modulating eye migration. The unexpected expression of the visual opsins from the phototransduction pathway in the skin translates illumination differences and generates retinoic acid gradients that underlie the generation of asymmetry. Identifying the genetic underpinning of this unique developmental process answers long-standing questions about the evolutionary origin of asymmetry, but it also provides insight into the mechanisms that control body shape in vertebrates. National Natural Science Foundation of China [31130057, 31461163005, 31530078, 31472269, 31472262, 31472273]; State 863 High Technology R&D Project of China [2012AA092203, 2012AA10A408, 2012AA10A403-2]; Education and Research of Guangdong Province [2013B090800017]; Taishan Scholar Climb Project Fund of Shandong of China; Taishan Scholar Project Fund of Shandong of China for Young Scientists; Shanghai Universities First-class Disciplines Project of Fisheries; Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning; Shanghai Municipal Science, Special Project on the Integration of Industry info:eu-repo/semantics/publishedVersion
- Published
- 2016