1. Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
- Author
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Oelsner, E. C., Pottinger, T. D., Burkart, K. M., Allison, M., Buxbaum, S. G., Hansel, N. N., Kumar, R., Larkin, E. K., Lange, L. A., Loehr, L. R., London, S. J., O'Connor, G. T., Papanicolaou, G., Petrini, M. F., Rabinowitz, D., Raghavan, S., Redline, S., Thyagarajan, B., Tracy, R. P., and Wilk, J. B.
- Subjects
OBSTRUCTIVE lung diseases ,CELL adhesion molecules ,BIOMARKERS ,SPIROMETRY ,SELECTINS ,ENDOTHELINS - Abstract
Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV
1 using instrumental variables. Methods: Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (−29 mL and −34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (−22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1 . The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1 , associations for ICAM-1 and P-selectin do not appear causal. [ABSTRACT FROM AUTHOR]- Published
- 2013
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