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Objective The upregulation of 5-amino-4-imidazolecarboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC) may affect tumorigenesis and multiple myeloma (MM) development. Materials and Methods A total of 97 patients with MM and 102 healthy control patients were included in the study. The SNaPshot technique was used to detect the ATIC gene polymorphisms. Linkage disequilibrium (LD) and haplotype analyses were conducted using SHEsis software. Results The genotype distribution or allele frequency of rs3772078 and rs16853834 was significantly different between the patients with MM and the healthy control patients (all P  <.05). The rs16853834 A allele, rs3772078 CT genotype, and C allele were associated with a decreased risk of MM (all P  <.05). Five single-nucleotide polymorphism combinations showed strong LD. Three haplotypes were associated with MM risk (all P  <.05). We found that ATIC rs7604984 was significantly associated with serum lactate dehydrogenase levels (P  = .050). Conclusion We determined that the rs3772078 and rs16853834 polymorphisms are associated with a decreased risk of MM. [ABSTRACT FROM AUTHOR]

Toll-like receptors (TLRs) are well known to play a critical role in antiviral and antitumor response. Available evidence has demonstrated that TLRs are implicated in the immunopathogenesis of hepatitis B virus (HBV) infection and tumor carcinogenesis. Therefore, we performed the present study to investigate the relationship with TLR3 gene polymorphisms and the risk of HBV-related liver disease in a Chinese population. A total of 623 individuals were included: 172 chronic hepatitis B (CHB) patients, 91 HBV-related liver cirrhosis (LC) patients, 174 HBV-related hepatocellular carcinoma (HCC) patients, and 186 healthy controls. Allelic and genotypic frequencies of TLR3 rs1879026 and rs3775290 polymorphisms were detected by PCR-RFLP and DNA sequencing analysis. Association analysis showed that the TT genotype of TLR3 rs3775290 was associated with a decreased risk for CHB, HBV-related LC, and HCC (OR = 0.52, 95% CI: 0.27–0.99, P = 0.048; OR = 0.32, 95% CI: 0.14–0.76, P = 0.010; OR = 0.49, 95% CI: 0.26–0.92, P = 0.027). Nevertheless, a lack of association was found between TLR3 rs1879026 and HBV-related liver diseases. In addition, haplotype analysis revealed that individuals who carried the GT haplotype might have a decreased risk of HBV-related liver diseases. The results indicated that genetic variant in TLR3 gene rs3775290 polymorphisms may be a protective factor for CHB, HBV-related LC, and HCC in the Chinese population. [ABSTRACT FROM AUTHOR]