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Your search keyword '"Omar, Walaa E."' showing total 2 results
Start Over Author "Omar, Walaa E." Topic genetic predisposition to disease
2 results on '"Omar, Walaa E."'

1. Angiotensin-Converting Enzyme 2 (G8790A) Gene Polymorphism as a Risk Factor for COVID-19 in Egyptian Children and Adolescents.

Author

Ibraheem AAA, Saleh SA, Emam AA, Yousef AA, Abdulhay M, Haridi MK, Wahba AA, Al-Fahham MM, Selim DM, Razek SA, Sorour EI, Abouzied ESHF, Ismail AH, Mohamed SA, Soliman AA, Shehata H, Arab F, Rashad MLM, Hafez SFM, Abdelkhalek K, Ibrahim DM, Ashraf B, Saleh ASE, Fouad RA, Omar WE, Nabil RM, Ramadan RA, El-Sehsah EM, Afify MR, Bawazir Y, Mustafa M, Daghistani Y, Thabit RA, Salah W, Almoraie LM, Aljamei HM, Hummdi LA, Arishi EA, Salem HF, Massoud YM, Khalil DM, Raouf BMA, Elmikaty HA, El-Gaaly SAA, Fakhreldin AR, and Hashem MIA

Subjects
Humans, Child, Egypt, Adolescent, Male, Female, Case-Control Studies, Prospective Studies, Risk Factors, Genotype, Polymorphism, Single Nucleotide, Child, Preschool, Severity of Illness Index, Alleles, Polymorphism, Genetic, COVID-19 genetics, Angiotensin-Converting Enzyme 2 genetics, Genetic Predisposition to Disease, SARS-CoV-2
Abstract

Objective: Recently, angiotensin-converting enzyme 2 (ACE2) gene has emerged as a potential candidate gene for susceptibility to SARS-CoV-2 infection. We investigated whether ACE2 G8790A (rs2285666) polymorphism could be a genetic marker for susceptibility to COVID-19 and disease severity in Egyptian children and adolescents., Methods: This was a prospective case-control study included 580 cases diagnosed with COVID-19, and 580 matched control children and adolescents. The ACE2 G8790A (rs2285666) polymorphism was genotyped using polymerase chain reaction (PCR) and ACE2 serum level was measured by ELISA., Results: The ACE2 A/A genotype and A-allele were significantly more represented in cases with COVID-19 as compared to control group (44% vs. 30%; OR = 2.83; [95% CI: 1.27-2.63]; p = 0.006; for the A/A genotype) and (65% vs. 51%; OR = 1.9; [95% CI: 1.06-1.72]; p = 0.01; for the A-allele). The presence of ACE2 G/G genotype was an independent risk factor for severe disease (adjusted OR: 2.08; [95% CI: 1.57-6.78]; p = 0.003)., Conclusion: The ACE2 G8790A (rs2285666) polymorphism may confer susceptibility to COVID-19 in Egyptian children and adolescents. The ACE2 G/G genotype and G-allele was associated with lower ACE2 serum levels and may constitute independent risk factors for disease severity., (© 2025 Wiley Periodicals LLC.)

Published
2025
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2. Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents.

Author

Boraey NF, Bebars MA, Wahba AA, Abd El Lateef HM, Attia MA, Elsayed AH, Rashed KA, Sorour EI, Ahmed MF, Abd-Elrehim GAB, Soliman AA, Shehab MMM, Elhindawy EM, Ibraheem AAA, Shehata H, Yousif YM, Hashem MIA, Ahmed AA, Emam AA, Gameil DM, Abdelhady EM, Abdelkhalek K, Morsi WEMA, Selim DM, Razek SA, Ashraf B, Saleh ASE, Eltrawy HH, Alanwar MI, Fouad RA, Omar WE, Nabil RM, Abdelhamed MR, Ibrahim MY, Malek MM, Afify MR, Alharbi MT, Nagshabandi MK, Tarabulsi MK, Qashqary ME, Almoraie LM, Salem HF, Rashad MM, El-Gaaly SAA, El-Deeb NA, Abdallah AM, Fakhreldin AR, Hassouba M, Massoud YM, Attaya MSM, and Haridi MK

Subjects
Humans, Child, Egypt, Adolescent, Male, Female, Case-Control Studies, Genotype, Child, Preschool, Alleles, INDEL Mutation, Gene Frequency, Risk Factors, Renin-Angiotensin System genetics, COVID-19 genetics, Peptidyl-Dipeptidase A genetics, Genetic Predisposition to Disease, SARS-CoV-2, Polymorphism, Genetic
Abstract

Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents., Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA., Results: The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46-3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49-2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6-9.7]; P < 0.001., Conclusions: The ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents., Impact: Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19. To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents. The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19. The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies., (© 2024. The Author(s).)

Published
2024
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