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36 results on '"Perry, John R. B."'

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1. Protein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.

2. Genetic links between ovarian ageing, cancer risk and de novo mutation rates.

3. Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study.

4. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

5. GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.

6. Genetic basis of falling risk susceptibility in the UK Biobank Study.

7. Genetic predisposition to mosaic Y chromosome loss in blood.

8. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

9. Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

10. Identification of nine new susceptibility loci for endometrial cancer.

11. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

12. Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

13. Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

14. The genetic architecture of type 2 diabetes.

15. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

16. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

17. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

18. Partitioning heritability by functional annotation using genome-wide association summary statistics.

19. Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

20. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

21. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

22. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

23. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

24. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

25. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

26. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

27. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects

28. The UK10K project identifies rare variants in health and disease

29. Associations between Potentially Modifiable Risk Factors and Alzheimer Disease : A Mendelian Randomization Study

30. Genetic studies of body mass index yield new insights for obesity biology

31. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

32. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

33. GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

34. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

35. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

36. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

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