1. Maternal perspective of Croatian genetic diversity
- Author
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Lucija Barbarić, Marina Korolija, Korana Lipovac, Viktorija Sukser, Walther Parson, Bettina Zimmermann, and Sara Rožić
- Subjects
Croatian ,mtDNA control region ,Male ,Genetic diversity ,Principal Component Analysis ,Croatia ,Perspective (graphical) ,Genetic Variation ,High-Throughput Nucleotide Sequencing ,Locus Control Region ,DNA, Mitochondrial ,Polymerase Chain Reaction ,language.human_language ,Pathology and Forensic Medicine ,Geography ,Genetics, Population ,Haplotypes ,Evolutionary biology ,Databases, Genetic ,Genetics ,language ,Humans ,Female ,Southeastern Europe ,EMPOP database ,Forensic Science - Abstract
In order to investigate Croatian mitochondrial DNA variability and to generate a national forensic reference database, complete control region sequences were generated for 200 randomly selected individuals. In general, almost exclusively Westeurasian lineages were found, associated with a high level of genetic diversity. The most frequent haplogroups were H (25.5%) and U (22%), followed by HV (11.5%), T (10%), N (8%), K, J, R (7.5% each). We report a yet undescribed sub-lineage of East Asian provenance that belongs to haplogroup A, which has been rarely described in the Westeurasian gene pool. The interpopulation comparison confirmed that Croatian mtDNA variability fits within a broader South and Southeastern Europe (SEE) maternal genetic landscape. Besides population genetic studies, the dataset will be used as national reference database in forensic and missing persons casework and provided via EMPOP to the forensic genetic community.
- Published
- 2019