1. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
- Author
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Laurie Burdette, Xiao-Hang Zhao, Guo-Lan Xing, Yin Li, Chaoyu Wang, Yu-Tang Gao, Jin Wang, William Wheeler, Ying Huang, Shengli Zhou, Haijun Yang, Teng Ma, Peter Kraft, She-Gan Gao, Chang-Wei Feng, Xiaoping Miao, Li-Sha Chen, Shu-Wei Ren, Hongbing Shen, Dongxin Lin, Zhaoming Wang, Yifeng Zhou, Woon-Puay Koh, Ilyar Sheyhidin, Zhao Xueke, Yi-Min Mao, Wei Hua Jia, Li Bei, Ji-Lin Li, Wen-Bin Yue, Wancai Yang, Xiu-Qing Peng, Maxwell P. Lee, Ya-Li Liu, Xiao Liu, Yang Ke, Liangdan Sun, Ying-Fa Zhou, Charles C. Chung, Nan Hu, Bin Liu, Xiao-Shan Feng, Margaret A. Tucker, Ti Ding, Yu Liu, Amy Hutchinson, Alisa M. Goldstein, Xiu-Min Li, En-Min Li, Kan Zhai, Yan Li, Zhi-Qing Yuan, Jing Liu, Jian-Wei Ku, Yuan Yuan, Yan-Rui Zhang, Zhihua Liu, Guang-Yan Lei, Qi-De Bao, Qimin Zhan, Wei Zheng, Wu Wei, Sa Tang, Er-Tao Guo, Qirenwang Qige, Linda M. Liao, Yu-Hua Yang, Jin-Hu Fan, Shuqing Chen, Wen-Jun Yang, Neal D. Freedman, Xi Chen, Kevin B. Jacobs, Jianhua Fu, Philip R. Taylor, Ze-Zhong Tang, Stephen J. Chanock, Kai Yu, Meredith Yeager, Zhou Fuyou, Ran Wang, Yan-Long Hu, Xiao-Ou Shu, Jeff Yuenger, Wen Tan, Feng Li, Ling Yuan, Guangfu Jin, Zhi-Chao Hou, Ji-Li Cui, Jie He, Changdong Lu, Jing-Jing Han, Zhibin Hu, Xuejun Zhang, Chunling Liu, Min Han, Yi Xin Zeng, Hong-Zhang Hao, Chen Wu, Jian-Min Yuan, Chuanhai Guo, Bao-Chi Liu, Li Sun, Xin-Min Li, Christian C. Abnet, Long-Qi Chen, Liu Qin Yang, Yan Qiao, Wei Zhang, Peng Zhang, Mitchell H. Gail, Hong-Li Lin, Lixuan Wei, Zhou Wang, Tangchun Wu, Hui Meng, Joseph F. Fraumeni, Dongyun Zhang, Guo Yuan, Carol Giffen, Zong-Min Fan, Lu-Wen Wang, Dianke Yu, Sanford M. Dawsey, Bao-Gen Ma, Xue-Min Li, Jun-Yan Hong, Jiang Chang, Xue-Ping Fan, Ai-Li Li, Yong-Bing Xiang, Mei Zhang, Fang-Heng Zhu, Qing-Peng Kong, Li-Dong Wang, Li Wang, Dong Xie, Xianbo Zuo, Xin Song, Jing-Li Ren, You-Lin Qiao, Liang Wang, Weixing Zhao, Zhonghu He, Han Xuena, and Ai-Qun Wu
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Oncology ,Male ,Risk ,medicine.medical_specialty ,Esophageal Neoplasms ,Genotype ,Locus (genetics) ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Internal medicine ,Genetics ,medicine ,SNP ,Humans ,Genetic Predisposition to Disease ,Alleles ,030304 developmental biology ,Genetic association ,0303 health sciences ,Case-control study ,Odds ratio ,Middle Aged ,3. Good health ,Genetic Loci ,030220 oncology & carcinogenesis ,Case-Control Studies ,Carcinoma, Squamous Cell ,Female ,Esophageal Squamous Cell Carcinoma ,Genome-Wide Association Study - Abstract
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC.
- Published
- 2014