1. Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.
- Author
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Lande, Leah, Alexander, David C., Wallace Jr., Richard J., Kwait, Rebecca, Iakhiaeva, Elena, Williams, Myra, Cameron, Andrew D. S., Olshefsky, Stephen, Devon, Ronit, Vasireddy, Ravikiran, Peterson, Donald D., Falkinham III, Joseph O., Wallace, Richard J Jr, and Falkinham, Joseph O 3rd
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MYCOBACTERIUM avium , *HOUSEHOLDS , *MUNICIPAL water supply , *LUNG infections , *COMMUNITIES , *PUBLIC health surveillance , *RESEARCH , *MICROBIAL ecology , *BIOLOGICAL evolution , *SEQUENCE analysis , *RESEARCH methodology , *HISTORY , *EVALUATION research , *MEDICAL cooperation , *AQUATIC microbiology , *COMPARATIVE studies , *GENOTYPES , *GENOMES , *MYCOBACTERIAL diseases , *GRAM-positive bacteria - Abstract
Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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