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Your search keyword '"Kukurba, Kim R"' showing total 2 results
Start Over Author "Kukurba, Kim R" Topic genomics
2 results on '"Kukurba, Kim R"'

1. The landscape of genomic imprinting across diverse adult human tissues.

Author

Baran Y, Subramaniam M, Biton A, Tukiainen T, Tsang EK, Rivas MA, Pirinen M, Gutierrez-Arcelus M, Smith KS, Kukurba KR, Zhang R, Eng C, Torgerson DG, Urbanek C, Li JB, Rodriguez-Santana JR, Burchard EG, Seibold MA, MacArthur DG, Montgomery SB, Zaitlen NA, and Lappalainen T

Subjects
Adult, Alleles, Cluster Analysis, DNA Methylation, Databases, Nucleic Acid, Female, Gene Expression Regulation, Genetic Variation, Genotype, Humans, Male, Organ Specificity genetics, Polymorphism, Single Nucleotide, Reproducibility of Results, Sex Factors, Genomic Imprinting, Genomics
Abstract

Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2 shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues., (© 2015 Baran et al.; Published by Cold Spring Harbor Laboratory Press.)

Published
2015
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2. The landscape of genomic imprinting across diverse adult human tissues

Author

Baran, Yael, Subramaniam, Meena, Biton, Anne, Tukiainen, Taru, Tsang, Emily K, Rivas, Manuel A, Pirinen, Matti, Gutierrez-Arcelus, Maria, Smith, Kevin S, Kukurba, Kim R, Zhang, Rui, Eng, Celeste, Torgerson, Dara G, Urbanek, Cydney, GTEx Consortium, Li, Jin Billy, Rodriguez-Santana, Jose R, Burchard, Esteban G, Seibold, Max A, MacArthur, Daniel G, Montgomery, Stephen B, Zaitlen, Noah A, and Lappalainen, Tuuli

Subjects
Adult, Male, Genotype, Nucleic Acid, Bioinformatics, Human Genome, Reproducibility of Results, Genetic Variation, Genomics, Single Nucleotide, DNA Methylation, Biological Sciences, Medical and Health Sciences, GTEx Consortium, Genomic Imprinting, Databases, Sex Factors, Gene Expression Regulation, Organ Specificity, Genetics, Humans, Cluster Analysis, Female, Polymorphism, Alleles
Abstract

Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2 shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues.

Published
2015

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