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Start Over Descriptor "So-ochim-tang-gamibang" Topic genotoxicity
3 results on '"So-ochim-tang-gamibang"'

1. Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

Author

Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi, and In Chul Jung

Subjects
SOCG, So-ochim-tang-gamibang, Genotoxicity, Bacterial reverse mutation test, Chromosomal aberration test, Micronucleus test, Other systems of medicine, RZ201-999
Abstract

Abstract Background So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety evaluation. Methods SOCG was evaluated for potential genotoxic effects using the standard three tests recommended by the Ministry of Food and Drug Safety (MFDS) of Korea. These tests were the bacterial reverse mutation test (Ames test), in vitro mammalian chromosomal aberration test using Chinese hamster lung cells, and in vivo micronucleus test using ICR mice. Results The Ames test with Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and the Escherichia coli strain WP2uvrA(pKM101) showed that SOCG did not induce gene mutations at any dose level in all of the strains. SOCG did not induce any chromosomal aberrations in the in vitro chromosomal aberration test (for both the 6 and 24 h test) and the in vivo micronucleus test. Conclusions Based on the results of these tests, it was concluded that SOCG does not exhibit any genotoxic risk under the experimental conditions of this study.

Published
2018
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3. Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

Author

In Chul Jung, Yang-Chun Park, Eun Seok Kim, Mi-Young Lee, Jeong June Choi, and Mirim Jin

Subjects
0301 basic medicine, Male, Salmonella typhimurium, Bacterial reverse mutation test, Biology, Gene mutation, Pharmacology, So-ochim-tang-gamibang, medicine.disease_cause, Chinese hamster, Ames test, Cell Line, 03 medical and health sciences, Mice, Cricetulus, In vivo, Cricetinae, Micronucleus test, medicine, Escherichia coli, Animals, Micronuclei, Chromosome-Defective, Chromosome Aberrations, Mice, Inbred ICR, Micronucleus Tests, Mutagenicity Tests, Plant Extracts, lcsh:Other systems of medicine, General Medicine, Korean medicine, lcsh:RZ201-999, biology.organism_classification, Medicine, Korean Traditional, In vitro, SOCG, 030104 developmental biology, Complementary and alternative medicine, Chromosomal aberration test, Genotoxicity, Mutagens, Research Article
Abstract

Background So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety evaluation. Methods SOCG was evaluated for potential genotoxic effects using the standard three tests recommended by the Ministry of Food and Drug Safety (MFDS) of Korea. These tests were the bacterial reverse mutation test (Ames test), in vitro mammalian chromosomal aberration test using Chinese hamster lung cells, and in vivo micronucleus test using ICR mice. Results The Ames test with Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and the Escherichia coli strain WP2uvrA(pKM101) showed that SOCG did not induce gene mutations at any dose level in all of the strains. SOCG did not induce any chromosomal aberrations in the in vitro chromosomal aberration test (for both the 6 and 24 h test) and the in vivo micronucleus test. Conclusions Based on the results of these tests, it was concluded that SOCG does not exhibit any genotoxic risk under the experimental conditions of this study.

Published
2017

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