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Background and purpose: Human papillomavirus (HPV) often infects humans through sexual contact. Men are carriers of the HPV virus and inadvertently transmit the virus to their sexual partners while being asymptomatic. In many countries strategies are focused on controlling the virus in women and the role of men is ignored. The aim of this study was to determine the prevalence of HPV infection and its common genotypes in men in order to facilitate designing and implementing national prevention programs. Materials and methods: In this cross-sectional study, PCR and hybridization methods were used to determine 37 different HPV genotypes. The participants included 188 men attending Central Laboratory of Academic Center for Education, Culture, and Research, Mashhad Branch between autumn 2020 and winter 2021. Results: In this study, 56.9% of the total population were infected with at least one of the HPV genotypes. Overall, 26 different HPV high-risk and low-risk genotypes were identified. The most common low-risk genotypes were HPV6 (50.5%), 11 (15%), 42 and 91 (11.2%). The most common highrisk genotype was HPV66 (9.3%). Conclusion: Men play an important role in transmitting the virus and are considered as the reservoir of HPV infection. The prevalence of HPV was high in current population, therefore, HPV screening in men can be very helpful in preventing the spread of infection. [ABSTRACT FROM AUTHOR]

Background and purpose: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Awareness of the prevalence of different HPV genotypes in Iran will facilitate implementation of national prevention and vaccination programs. The aim of this study was to investigate the prevalence of HPV infection and the association of different genotypes with Pap smear results. Materials and methods: In this cross-sectional study, 502 married women attending Central Laboratory of Academic Center for Education, Culture, and Research in Mashhad were selected by nonprobability easy sampling in 2018-2019. Cervical cytology specimens were examined for 32 different HPV genotypes using PCR and hybridization. Descriptive statistics, Chi-square and Fisher's exact tests were used to analyze the data. Results: Out of 502 samples 26.5% were infected with HPV. The most common genotypes in all HPV+ samples were the low risk genotype 6 (35.3%) and the high risk genotype 16 (17.3%). According to findings, HPV infection and the HPV genotype were significantly associated with progression of cellular changes to abnormality (P<0.05). Conclusion: Due to the high prevalence of HPV in population studied, earlier diagnosis and genotyping of HPV could be helpful in preventing cervical malignancies. [ABSTRACT FROM AUTHOR]