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Reservoir dams have varying degrees of damage and hidden dangers under long-term and complex operating conditions, engineering problems mainly focus on the gradual decrease of seepage stability and guarantee rate of deformation and stability of dam foundation. However, due to the complexity of the dam foundation structure and the surrounding environment, the performance degradation of the dam foundation caused by the aging of the impervious structure lacks a systematic study of the process and its mechanism, In particular, the determination of relevant seepage parameters is complicated, moreover the simulation accuracy of its inversion model is not enough to meet the needs of long-term stability evaluation of the dam foundation. In order to study the seepage stability of the dam foundation of the reservoir during operation, a three-dimensional finite element model of complex geological bodies is combined with artificial neural network to establish a model of inversion of seepage field in the dam foundation, According to the 22 groups of predicted grouting schemes, five groups of representative grouting schemes were selected and the seepage characteristics of the same location were analyzed. The conclusions as below: (1) the inversion predicted that when the permeability coefficient was in the range of 3.0 × 10−6 cm/s to 5.0 × 10−6 cm/s, the change range was small, and the curtain's anti-seepage effect was more obvious. (2) The analysis of the dam base surface and the bottom of the grouting area shows that the difference between the water head and seepage gradient of the dam base surface and the bottom of the grouting area under the GZ 7 and GZ 3 schemes vary significantly with the grouting effect. Among them, especially in the GZ 3 scheme, the key parts of the dam foundation surface F2 ~ F4: the seepage gradient value gradually increases, and all reach the maximum value in the GZ 3 scheme; For G6 ~ G15 at the bottom of the grouting area, the water head value under the GZ 3 scheme is gradually smaller than the three grouting schemes of GZ 11 , GD 3 and GD 7 , as the water head value gradually decreases, the anti-seepage effect becomes more and more obvious. The above results show that the inversion prediction range is in good agreement with the actual law, when the permeability coefficient is within the predicted range, the anti-seepage effect is optimal. (3) The difference of the water head and seepage gradient difference between the dam foundation and the grouting area near the curtain changes significantly with the grouting effect. Characteristics of seepage field in key parts of the dam foundation under the six curtain grouting coefficients, the water head value F1-F2 decreased by 75%, F3-F13 decreased by 28%, the seepage gradient value F1-F2 decreased by 88%, and F3-F13 decreased by 29%, namely the grouting effect of the dam foundation and the grouting area gradually weakens as the distance between the characteristic part and the curtain increases. The research in this paper can provide a theoretical reference for the analysis and evaluation of dam seepage conditions. [ABSTRACT FROM AUTHOR]