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Your search keyword '"Somatic Hypermutation, Immunoglobulin genetics"' showing total 33 results

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33 results on '"Somatic Hypermutation, Immunoglobulin genetics"'

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1. A branching stochastic evolutionary model of the B-cell repertoire.

2. Long-primed germinal centres with enduring affinity maturation and clonal migration.

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3. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.

4. Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches.

5. Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.

6. BCR selection and affinity maturation in Peyer's patch germinal centres.

7. Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination.

8. Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification.

9. Transient AID expression for in situ mutagenesis with improved cellular fitness.

10. A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.

11. High affinity IgM(+) memory B cells are generated through a germinal center-dependent pathway.

12. Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

13. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

14. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

15. Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction.

16. Clonal selection in the germinal centre by regulated proliferation and hypermutation.

17. Immunology: To affinity and beyond.

18. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

19. Molecular characterization of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma: antigen-driven origin and IGHV4-34 as a particular subgroup of the non-GCB subtype.

20. AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.

21. Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

22. Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.

23. Exploration of factors affecting the onset and maturation course of follicular lymphoma through simulations of the germinal center.

24. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

25. Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells.

26. The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.

27. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity.

28. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice.

29. Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus.

30. Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas.

31. Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes.

32. Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function.

33. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.