1. 20(S)-Ginsenoside Rg 2 amino acid derivatives for anti hemorrhagic shock: Synthesis, characterization and evaluation.
- Author
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Dong Q, Xie H, Liu J, Su J, An Y, Shi F, Lin F, and Liu J
- Subjects
- Rats, Animals, Oxidative Stress, Amino Acids, Hypoxia, Ginsenosides pharmacology, Ginsenosides therapeutic use, Shock, Hemorrhagic drug therapy
- Abstract
The purpose of this study is to screen a novel Rg
2 derivative for anti hemorrhagic shock. Eight Rg2 amino acid ester derivatives were designed and synthesized, and their effects on hypoxia and shock were studied. Among them, the derivative 1 (D1) exhibited excellent anti hypoxia by promoting survival rate of H9c2 cells damaged by hypoxia. D1 improved physiological indicators of the rats in hemorrhagic shock, such as blood pressure, heart rate, lactate, acid-base balance, and alleviate oxidative stress and inflammatory damage. Its latent mechanisms were explored by a method of plasma metabolomics based on UPLC-QTOF-MS. As a result, a total of 16 biomarkers were identified involving 6 metabolic pathways. The results of this study contained that the derivative 1 could be considered as potent drug candidates for anti shock and deserved further research and development., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jihua Liu reports financial support was provided by Science and Technology Development Program of Jilin Province, National Key Research and Development Plan. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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