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Introduction: Mobile radiation, also known as non-ionizing radiation, has been shown to have an impact on the formulation of Gliclazide tablets. The study's objective was to examine the impact of mobile phone radiation on the physical and chemical characteristics of Gliclazide, an oral medication utilized to manage type 2 diabetes by boosting insulin production from the pancreas. Materials and Methods: The tablets were exposed to mobile radiation for different periods, and the effects were evaluated using various analytical techniques such as UV-spectrophotometer and Mass spectrophotometer. The study found that the physical and chemical properties of Gliclazide tablets were significantly affected by mobile phone radiation. The tablets exposed to mobile radiation for longer periods showed a change in stability. Results: Furthermore, mobile radiation caused changes in the properties of the tablets, leading to changes in effectiveness. The study also found that mobile radiation caused a decrease in the dissolution rate of Gliclazide tablets, which can affect the bioavailability of the medication. The conclusion of the study revealed that mobile phone radiation significantly impacted the physical and chemical properties of Gliclazide tablets, potentially altering the medication's bioavailability. Conclusion: Therefore, it is important to consider the potential impact of mobile radiation on the formulation of Gliclazide tablets and other similar medications. More research is needed to understand the full extent of the effects of mobile radiation on medication formulations and to develop methods to protect medications from the effects of mobile radiation. [ABSTRACT FROM AUTHOR]