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Introduction: This study aimed to analyze the spiking patterns of subthalamic nucleus and globus pallidus coupling in hyperdirect pathway in healthy primates and in Parkinson’s disease using a conductance‑based model. The effect of calcium membrane potential has also been investigated. Materials and Methods: System of coupled differential equation arising from the conductance‑based model has been simulated using ODE45 in MATLAB 7.14 to analyze the spiking patterns. Results: Analysis of spiking patterns suggests that subthalamic nucleus with synaptic input from globus pallidus in hyperdirect pathways is capable of showing two types of spiking pattern – irregular and rhythmic. Characterization of spiking patterns in healthy and Parkinson condition has been done based on their frequency, trend, and spiking rate. Results indicate that rhythmic patterns does not account for Parkinson’s disease. Further, calcium membrane potential is an important parameter to target for identifying the cause of this disease. Conclusion: This work demonstrates that subthalamic nucleus and globus pallidus coupling in hyperdirect pathway can account for Parkinson’s symptoms. However, the entire process of excitations and inhibition caused by glutamate and GABA receptors is limited by the timing of depolarization of the model. There is improvement in the correlation between healthy and Parkinson’s patterns by increase in calcium membrane potential, however, for a limited time. [ABSTRACT FROM AUTHOR]

(GP) – The External globus pallidus neuron & (STN) – The Subthalamic nucleus in Parkinsonism synchronise their firing in time with dawdling or superior oscillations in cortex. An extensive variety of electrophysiological performance characteristic of rat subthalamic neurons is exhibited by the model cell. Measured by increased thrashing of movement, tremors, and communication slurring, Parkinson’s disease (PD) is a devastating motor scheme disorder. Independent wavering of both the neurons underlies stimulant movement and is essential for synaptic incorporation. PD characteristic is the abnormal low-frequency rhythmic bursting in neurons. This infiltrate work presents a considerable measure forward in GPe and STN research and might be effectively implemented into experimental exercise. [ABSTRACT FROM AUTHOR]

Parkinson disease alters the information patterns in movement related pathways in brain. Experimental results performed on rats show that the activity patterns changes from single spike activity to mixed burst mode in Parkinson disease. However the cause of this change in activity pattern is not yet completely understood. Subthalamic nucleus is one of the main nuclei involved in the origin of motor dysfunction in Parkinson disease. In this paper, a single compartment conductance based model is considered which focuses on subthalamic nucleus and synaptic input from globus pallidus (external). This model shows highly nonlinear behavior with respect to various intrinsic parameters. Behavior of model has been presented with the help of activity patterns generated in healthy and Parkinson condition. These patterns have been compared by calculating their correlation coefficient for different values of intrinsic parameters. Results display that the activity patterns are very sensitive to various intrinsic parameters and calcium shows some promising results which provide insights into the motor dysfunction. [ABSTRACT FROM AUTHOR]