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2 results on '"ΔGlucose"'

1. Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes a retrospective study from glucagon stimulation test

Author

Yumi Takiyama, Hidemitsu Sakagami, Yukihiro Fujita, Tsuguhito Ota, Mao Sato, Tsuyoshi Yanagimachi, Masakazu Haneda, Atsuko Abiko, Yasutaka Takeda, Tomoe Abe, and Ryoichi Bessho

Subjects
Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, Type 2 diabetes, Kidney Function Tests, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Glucagon, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Japan, Internal medicine, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, Retrospective Studies, Creatinine, Kidney, Free fatty acid, lcsh:RC648-665, business.industry, Incidence, Gluconeogenesis, ΔGlucose, General Medicine, Middle Aged, Prognosis, medicine.disease, Hormones, Cross-Sectional Studies, medicine.anatomical_structure, Endocrinology, Diabetes Mellitus, Type 2, chemistry, 030220 oncology & carcinogenesis, Female, Liver function, business, Biomarkers, Follow-Up Studies, Glomerular Filtration Rate, Research Article, Kidney disease
Abstract

BackgroundGlucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucose and clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucose is associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs.MethodsA total of 209 subjects with type 2 diabetes who underwent GST during admission were included in this cross-sectional study. We defined the difference between plasma glucose at fasting and 6 min after intravenous injection of 1 mg glucagon as Δglucose. We assessed correlations between Δglucose and clinical parameters such as diabetic duration, BMI, HbA1c, beta cell function, serum free fatty acids (FFA) which is known to stimulate gluconeogenesis, liver function, the indices of liver function, renal function, and urinary albumin excretion (UAE).ResultsIn correlation analysis, Δglucose positively correlated to FFA and estimated glomerular filtration rate (eGFR), but inversely to serum creatinine and cystatin C, although Δglucose showed no correlation with both liver function and the indices of residual liver function. Multiple regression analysis revealed that Δglucose was an independent determinant for the eGFR after 1 year, equally BMI, HbA1c, serum lipids, and UAE, which are known as the predictors for the development of chronic kidney disease.ConclusionOur results suggest that Δglucose during GST might be related to gluconeogenesis in the kidney and could be the determinant of future renal function in type 2 diabetes.

Published
2019
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2. Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes:a retrospective study from glucagon stimulation test.

Author

Takeda, Yasutaka, Fujita, Yukihiro, Bessho, Ryoichi, Sato, Mao, Abe, Tomoe, Yanagimachi, Tsuyoshi, Sakagami, Hidemitsu, Abiko, Atsuko, Takiyama, Yumi, Ota, Tsuguhito, and Haneda, Masakazu

Subjects
*BLOOD sugar analysis, *CHRONIC kidney failure, *KIDNEY physiology, *LIVER physiology, *GLUCOSE metabolism, *BLOOD plasma, *BLOOD sugar, *CARBOHYDRATE metabolism, *CREATININE, *FATTY acids, *GLOMERULAR filtration rate, *GLUCAGON, *GLYCOSYLATED hemoglobin, *INTRAVENOUS injections, *KIDNEY function tests, *LIPIDS, *LIVER function tests, *TYPE 2 diabetes, *SERUM, *MULTIPLE regression analysis, *ALBUMINS, *BODY mass index, *CYSTATINS, *CROSS-sectional method, *RETROSPECTIVE studies, *PREPROCEDURAL fasting, *BLOOD, *DISEASE risk factors
Abstract

Background: Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucose and clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucose is associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs. Methods: A total of 209 subjects with type 2 diabetes who underwent GST during admission were included in this cross-sectional study. We defined the difference between plasma glucose at fasting and 6 min after intravenous injection of 1 mg glucagon as Δglucose. We assessed correlations between Δglucose and clinical parameters such as diabetic duration, BMI, HbA1c, beta cell function, serum free fatty acids (FFA) which is known to stimulate gluconeogenesis, liver function, the indices of liver function, renal function, and urinary albumin excretion (UAE). Results: In correlation analysis, Δglucose positively correlated to FFA and estimated glomerular filtration rate (eGFR), but inversely to serum creatinine and cystatin C, although Δglucose showed no correlation with both liver function and the indices of residual liver function. Multiple regression analysis revealed that Δglucose was an independent determinant for the eGFR after 1 year, equally BMI, HbA1c, serum lipids, and UAE, which are known as the predictors for the development of chronic kidney disease. Conclusion: Our results suggest that Δglucose during GST might be related to gluconeogenesis in the kidney and could be the determinant of future renal function in type 2 diabetes. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

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