1. [An update on glucocorticoid-induced osteoporosis].
- Author
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Krasselt M and Baerwald C
- Subjects
- Administration, Oral, Bone Density drug effects, Calcium, Dietary therapeutic use, Cholecalciferol therapeutic use, Dose-Response Relationship, Drug, Glucocorticoids therapeutic use, Humans, Long-Term Care, Osteoporosis diagnosis, Osteoporotic Fractures chemically induced, Prednisolone adverse effects, Prednisolone therapeutic use, Risk, Young Adult, Glucocorticoids adverse effects, Osteoporosis chemically induced
- Abstract
Glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis. Moreover, it is the most common reason for an osteoporosis among young adults. The clinical use of oral glucocorticoids increases the fracture incidence already within three months after starting the therapy. There does not seem to be a lower threshold: even doses as low as 2,5 mg of prednisone equivalent increase the risk of fractures. Adequate diagnostic and therapy are able to significantly reduce the resulting fracture risk. This article will discuss the pathophysiology of glucocorticoid-induced osteoporosis and give a summary of the current recommendations including the recently updated German guidelines., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2016
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