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Objective: The aim of this research is to study skin autofluorescence and the associations between skin glycated proteins and clinical characteristics of healthy and unhealthy subjects for noninvasive screening of diabetes and cardiovascular disease (CVD) risks. Background data: Accumulated advanced glycation endproducts (AGEs) promote increased oxidative stress and inflammation, as well as cross-linking of proteins leading to tissue damage and several diseases, including diabetes. Materials and methods: One hundred and four subjects with or without diabetes and stroke aged 20-80 years and with Fitzpatrick skin type (I to IV) participated in this study. The fluorescence spectrometer was used to illuminate a skin surface of 1 cm 2 . The skin of forearm was positioned on the spectrometer to assess skin AGEs. Anthropometric data and body composition also were evaluated. Results: Elevated skin autofluorescence was found in subjects >50 years old, as well as in patients with insulin resistance (IR), diabetes, and stroke. There was a positive correlation between the skin autofluorescence and age ( r  = 0.7, p  = 0.0001), body mass index (BMI) ( r  = 0.5, p  = 0.001), body fat ( r  = 0.5, p  = 0.0001), waist circumference ( r  = 0.45, p  = 0.001), and systolic blood pressure (BP) ( r  = 0.45, p  = 0.0001). Conclusions: Elevated skin autofluorescence can provide a noninvasive screening of diabetes and CVD risks.