1. Cytotoxic 9,19-cycloartane Triterpenoids from the Roots of Actaea dahurica.
- Author
-
Wang XY, Li CJ, Ma J, Li C, Huang JW, Wang N, Shen CJ, and Zhang DM
- Subjects
- Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, China, Glycosides isolation & purification, HeLa Cells, Humans, MCF-7 Cells, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Triterpenes isolation & purification, Actaea chemistry, Glycosides pharmacology, Plant Roots chemistry, Triterpenes pharmacology
- Abstract
Eight undescribed 9,19-cycloartane type triterpenoid glycosides (cimdalglnoside A-H) and ten known analogues were obtained from the phytochemical research on the roots of Actaea dahurica (syn. Cimicifuga dahurica). All compounds were characterised by spectroscopic experiments, and chemical method. All the compounds isolated were assayed for cytotoxicity to five human cancer cell lines. Cimdalglnoside G showed promising cytotoxicities against Hela, and MCF-7 cell lines with IC
50 values at 7.7 and 12.2 μM., (Copyright © 2019 Elsevier B.V. All rights reserved.)- Published
- 2019
- Full Text
- View/download PDF