1. NIR/pH dual-responsive polysaccharide-encapsulated gold nanorods for enhanced chemo-photothermal therapy of breast cancer.
- Author
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Xu W, Wang J, Qian J, Hou G, Wang Y, Ji L, and Suo A
- Subjects
- Breast Neoplasms metabolism, Breast Neoplasms pathology, Chitosan pharmacology, Female, Humans, MCF-7 Cells, Breast Neoplasms drug therapy, Chitosan chemistry, Doxorubicin chemistry, Doxorubicin pharmacology, Drug Delivery Systems, Gold chemistry, Gold pharmacology, Hyaluronic Acid chemistry, Hyaluronic Acid pharmacology, Hyperthermia, Induced, Metal Nanoparticles chemistry, Metal Nanoparticles therapeutic use, Nanotubes chemistry, Phototherapy
- Abstract
Combination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepared by successively modifying GNR with DAHA via Au-catechol bonds, conjugating DOX onto DAHA moiety through Schiff base linkage, and coating HECS interlayer for charge-reversal and hyaluronic acid corona for tumor cell targeting. The resulting nanoplatform GNR-HA
DOX CH exhibited acid-triggered surface charge-reversal and pH/NIR dual-responsive drug release behaviors. The nanoplatform could be efficiently internalized into MCF-7 breast cancer cells and displayed greater cancer cell killing than individual modalities. Therefore, polysaccharide decoration could ensure the co-delivery of GNR and DOX into cancer cells, and the developed GNR-HADOX CH holds great potential for breast cancer treatment., (Copyright © 2019 Elsevier B.V. All rights reserved.)- Published
- 2019
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