1. On-mask detection of SARS-CoV-2 related substances by surface enhanced Raman scattering.
- Author
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Liu X, Xie R, Li K, Zhu Z, Huang X, He Q, Sun Z, He H, Ge Y, Zhang Q, Chen H, and Wang Y
- Subjects
- Humans, Spike Glycoprotein, Coronavirus analysis, Nanowires chemistry, Limit of Detection, Surface Properties, Spectrum Analysis, Raman methods, Gold chemistry, SARS-CoV-2 isolation & purification, Masks, COVID-19 diagnosis, COVID-19 virology
- Abstract
We have developed a convenient surface-enhanced Raman scattering (SERS) platform based on vertical standing gold nanowires (v-AuNWs) which enabled the on-mask detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related substances such as the Spike-1 protein and the corresponding pseudo-virus. The Spike-1 protein was clearly distinguished from BSA protein with an accuracy above 99 %, and the detection limit could be achieved down to 0.01 μg/mL. Notably, a similar accuracy was achieved for the pseudo-SARS-CoV-2 (pSARS-2) virus as compared to the pseudo-influenza H7N9 (pH7N9) virus. The sensing strategy and setups could be easily adapted to the real SARS-CoV-2 virus and other highly contagious viruses. It provided a promising way to screen the virus carriers by a fast evaluation of their wearing v-AuNWs integrated face-mask which was mandatory during the pandemic., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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