1. Influence of killer immunoglobulin-like receptor/HLA ligand matching on achievement of T-cell complete donor chimerism in related donor nonmyeloablative allogeneic hematopoietic stem cell transplantation.
- Author
-
Sobecks, R. M., Ball, E. J., Askar, M., Theil, K. S., Rybicki, L. A., Thomas, D., Brown, S., Kalaycio, M., Andresen, S., Pohlman, B., Dean, R., Sweetenham, J., Macklis, R., Bernhard, L., Cherni, K., Copelan, E., Maciejewski, J. P., and Bolwell, B. J.
- Subjects
HEMATOPOIETIC stem cell transplantation ,TRANSPLANTATION of organs, tissues, etc. ,ORGAN donors ,GRAFT rejection ,BONE marrow cells ,GRAFT versus host disease ,IMMUNOGLOBULINS ,HLA histocompatibility antigens - Abstract
Achievement of complete donor chimerism (CDC) after allogeneic nonmyeloablative hematopoietic stem cell transplantation (NMHSCT) is important for preventing graft rejection and for generating a graft-vs-malignancy effect. The alloreactivity of NK cells and some T-cell subsets is mediated through the interaction of their killer immunoglobulin-like receptors (KIRs) with target cell HLA/KIR ligands. The influence of KIR matching on the achievement of T-cell CDC after NMHSCT has not been previously described. We analyzed 31 patients undergoing T-cell replete related donor NMHSCT following fludarabine and 200 cGy TBI. Recipient inhibitory KIR genotype and donor HLA/KIR ligand matches were used to generate an inhibitory KIR score from 1 to 4 based upon the potential number of recipient inhibitory KIRs that could be engaged with donor HLA/KIR ligands. Patients with a score of 1 were less likely to achieve T-cell CDC (P=0.016) and more likely to develop graft rejection (P=0.011) than those with scores greater than 1. Thus, patients with lower inhibitory KIR scores may have more active anti-donor immune effector cells that may reduce donor chimerism. Conversely, patients with greater inhibitory KIR scores may have less active NK cell and T-cell populations, which may make them more likely to achieve CDC.Bone Marrow Transplantation (2008) 41, 709–714; doi:10.1038/sj.bmt.1705954; published online 14 January 2008 [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF