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Start Over Author "Netzel B" Topic graft vs host reaction
7 results on '"Netzel B"'

1. The concept of GvHD-suppression by in vitro treatment with antisera.

Author

Rodt H, Thierfelder S, Kolb HJ, Netzel B, Haas RJ, Wilms K, and Bender-Götze C

Subjects
Animals, Antibodies, Monoclonal immunology, Antibodies, Neoplasm administration & dosage, Antibodies, Neoplasm immunology, Bone Marrow immunology, Chimera, Dogs, Humans, Immune Tolerance, Methods, Mice, Mice, Inbred C57BL, Prognosis, T-Lymphocytes immunology, Antilymphocyte Serum therapeutic use, Bone Marrow Transplantation, Graft vs Host Reaction, Leukemia therapy
Published
1981
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2. Bone marrow transplantation in DLA-haploidentical canine littermates: fractionated total body irradiation (FTBI) and in vitro treatment of the marrow graft with anti-T-cell globulin (ATCG).

Author

Kolb HJ, Bodenberger U, Rodt HV, Rieder I, Netzel B, Grosse-Wilde H, Scholz S, and Thierfelder S

Subjects
Animals, Dogs, Dose-Response Relationship, Radiation, Graft Survival, Methotrexate pharmacology, T-Lymphocytes immunology, Transplantation, Homologous, X-Rays, Antilymphocyte Serum pharmacology, Bone Marrow Transplantation, Graft vs Host Reaction drug effects, Graft vs Host Reaction radiation effects
Published
1980

3. Antibody incubation of human marrow graft for prevention graft versus host disease.

Author

Haas RJ, Janka G, Netzel B, Rodt H, Thierfelder S, Helmig M, Eife R, Belohradsky BH, Kolb HJ, and Betke K

Subjects
Adolescent, Child, Female, Humans, Leukemia, Lymphoid therapy, Male, T-Lymphocytes immunology, Transplantation, Homologous, Antibodies, Bone Marrow Transplantation, Graft vs Host Reaction
Abstract

An in vitro incubation of incompatible donor bone marrow by xenogenic anti-T-cell globulin (ATG) suppressed an otherwise lethal GvH reaction in animal models. An application of this principle to clinical bone marrow transplantation was successfully tried in three patients with acute lymphoblastic leukemia. Preparation of the specific anti-human T-cell globulin (ATCG-H) was carried out by absorption of anti-human thymocyte globulin with liver-kidney homogenate, chronic lymphocytic leukemia cells of B-cell type, and erythrocytes. Subsequent testing revealed that the serum still reacted with human T-cells but no longer reduced the number of colony-forming units in culture (CFU-C). All three bone marrow recipients were treated by chemotherapeutic conditioning and total body irradiation followed by grafting of in vitro treated bone marrow from HLA-identical siblings. The transplantation of the bone marrow was well tolerated and no major side effects were encountered. No patient so far (24, 7, 6 months) has shown any signs of GvHD. The in vitro pretransplantation treatment of bone marrow with anti T-globulin may be a new approach to the prevention for GvHD in man.

Published
1980
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5. T-cell phenotypes in mixed leukocyte reactions and after bone marrow transplantation: are Ia-antigen on T-cells a marker for GvH reactions?

Author

Stünkel K, Bender-Götze C, Netzel B, and Thiel E

Subjects
Antibodies, Monoclonal, Antigen-Antibody Complex, Follow-Up Studies, Humans, Lymphocyte Culture Test, Mixed, Anemia, Aplastic therapy, Bone Marrow Transplantation, Graft vs Host Reaction, Histocompatibility Antigens Class II analysis, Leukemia therapy, T-Lymphocytes immunology
Published
1983
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6. Effect of anti-T-cell globulin on GVHD in leukemic patients treated with BMT.

Author

Rodt H, Kolb HJ, Netzel B, Haas RJ, Wilms K, Götze CB, Link H, and Thierfelder S

Subjects
Graft Rejection, Humans, Postoperative Complications therapy, Antilymphocyte Serum pharmacology, Bone Marrow Transplantation, Graft vs Host Reaction drug effects, Leukemia therapy, T-Lymphocytes immunology
Published
1981

7. Antilymphocytic antibodies and marrow transplantation. VI. Graft-versus-host tolerance in DLA-incompatible dogs after in vitro treatment of bone marrow with absorbed antithymocyte globulin.

Author

Kolb HJ, Rieder I, Rodt H, Netzel B, Grosse-Wilde H, Scholz S, Schäffer E, Kolb H, and Thierfelder S

Subjects
Animals, Antibodies, Colony-Forming Units Assay, Dogs, Hematopoiesis, Immune Tolerance, Immunosuppression Therapy, Rabbits immunology, T-Lymphocytes immunology, Antilymphocyte Serum pharmacology, Bone Marrow Transplantation, Graft vs Host Reaction, Histocompatibility Antigens
Published
1979

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