1. NEW POSSIBILITIES FOR THE TREATMENT OF ENTEROCOCCAL INFECTIOUS ENDOCARDITIS.
- Author
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Tyurin VP, Gudynovich VG, Volkova VL, Gvozdkov AL, Zharkov OB, Zhirova LG, Mezenova TV, and Gusaim TA
- Subjects
- Anti-Bacterial Agents administration & dosage, Echocardiography methods, Female, Heart Valve Prosthesis microbiology, Heart Valves microbiology, Humans, Male, Middle Aged, Russia epidemiology, Survival Analysis, Treatment Outcome, Daptomycin administration & dosage, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial microbiology, Endocarditis, Bacterial mortality, Endocarditis, Bacterial therapy, Enterococcus faecium drug effects, Enterococcus faecium isolation & purification, Gram-Positive Bacterial Infections diagnosis, Gram-Positive Bacterial Infections microbiology, Gram-Positive Bacterial Infections mortality, Gram-Positive Bacterial Infections therapy
- Abstract
This study was designed to analyze results of daptomycin therapy in 7 patients with enterococcal infectious endocarditis caused by Enterococcus faecium in two of them. Mean duration of therapy was 36.7 days. 70% of the strains proved resistant to gentamycin, 40% showed resistance to penicillin antibiotics, and 14.3% to vancomycin. Three patients suffered prosthetic valve endocarditis, six had elevated presepsin level (up to 768.8 pg/ml). 28,6% of the patients underwent valve prosthetic surgery. Hospital lethality was 14,3%. The effectiveness of ampicillin plus ceftriaxone treatment of gentanycin-resistant enterococci is discussed. Recommendation for the antibacterial treatment of enterococcal infectious endocarditis (ESC 2015) are provided.
- Published
- 2016