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Your search keyword '"Kallenberg, Cees GM"' showing total 3 results
Start Over Author "Kallenberg, Cees GM" Topic granulomatosis with polyangiitis
3 results on '"Kallenberg, Cees GM"'

1. Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis.

Author

Owczarczyk K, Cascino MD, Holweg C, Tew GW, Ortmann W, Behrens T, Schindler T, Langford CA, St Clair EW, Merkel PA, Spiera R, Seo P, Kallenberg CG, Specks U, Lim N, Stone J, Brunetta P, and Prunotto M

Subjects
Antigens, CD20 immunology, Azathioprine administration & dosage, Case-Control Studies, Cyclophosphamide administration & dosage, Double-Blind Method, Female, Follow-Up Studies, Granulomatosis with Polyangiitis drug therapy, Granulomatosis with Polyangiitis metabolism, Humans, Male, Microscopic Polyangiitis drug therapy, Microscopic Polyangiitis metabolism, Middle Aged, Prognosis, Remission Induction, Rituximab administration & dosage, Antigens, CD20 chemistry, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers metabolism, Granulomatosis with Polyangiitis pathology, Microscopic Polyangiitis pathology, Receptors, Fc metabolism
Abstract

BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinical response to RTX in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).METHODSA previously validated quantitative PCR-based (qPCR-based) platform was used to assess FCRL5 expression in patients with GPA/MPA (RAVE trial, NCT00104299).RESULTSBaseline FCRL5 expression was significantly higher in patients achieving complete remission (CR) at 6, 12, and 18 months, independent of other clinical and serological variables, among those randomized to RTX but not cyclophosphamide-azathioprine (CYC/AZA). Patients with baseline FCRL5 expression ≥ 0.01 expression units (termed FCRL5hi) exhibited significantly higher CR rates at 6, 12, and 18 months as compared with FCRL5lo subjects (84% versus 57% [P = 0.016], 68% versus 40% [P = 0.02], and 68% versus 29% [P = 0.0009], respectively).CONCLUSIONOur data taken together suggest that FCRL5 is a biomarker of B cell lineage associated with increased achievement and maintenance of complete remission among patients treated with RTX and warrant further investigation in a prospective manner.FUNDINGThe analysis for this study was funded by Genentech Inc.

Published
2020
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2. Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis

Author

Bossuyt, Xavier, Cohen Tervaert, Jan-Willem, Arimura, Yoshihiro, Blockmans, Daniel, Flores-Suárez, Luis Felipe, Guillevin, Loïc, Hellmich, Bernhard, Jayne, David, Jennette, J Charles, Kallenberg, Cees GM, Moiseev, Sergey, Novikov, Pavel, Radice, Antonella, Savige, Judith Anne, Sinico, Renato Alberto, Specks, Ulrich, Van Paassen, Pieter, Zhao, Ming-Hui, Rasmussen, Niels, Damoiseaux, Jan, Csernok, Elena, Jayne, David [0000-0002-1712-0637], and Apollo - University of Cambridge Repository

Subjects
Consensus, immune system diseases, Granulomatosis with Polyangiitis, Humans, Microscopic Polyangiitis, cardiovascular diseases, urologic and male genital diseases, skin and connective tissue diseases, respiratory tract diseases, Antibodies, Antineutrophil Cytoplasmic
Abstract

Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation. ispartof: Nature Reviews. Rheumatology vol:13 issue:11 pages:683-692 ispartof: location:United States status: published

Published
2020
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3. Staphylococcus aureus and Wegener's granulomatosis

Author

Popa, Eliane R, Stegeman, Coen A, Kallenberg, Cees GM, and Willem Cohen Tervaert, Jan

Subjects
Staphylococcus aureus, Superantigens, Receptors, Antigen, T-Cell, alpha-beta, autoimmunity, Granulomatosis with Polyangiitis, Receptors, Antigen, B-Cell, In Vitro Techniques, Staphylococcal Infections, Wegener's granulomatosis, Disease Models, Animal, Risk Factors, Meeting Abstract, Commentary, Animals, Humans, co-trimoxazole
Abstract

Wegener's granulomatosis (WG) is a form of systemic vasculitis. It is characterized by granulomatous inflammation in the upper and lower airways, vasculitis and necrotizing glomerulonephritis, and is strongly associated with antineutrophil cytoplasmic antibodies against proteinase 3. Since the etiology of the disease is not clear, treatment, consisting of corticosteroids and immunosuppressives, is nonspecific and associated with severe side effects. Pinpointing the trigger(s) of the disease would highly improve treatment. Clinical evidence shows that an infectious agent, the bacterium Staphylococcus aureus, is a risk factor for disease relapse, suggesting its involvement in the pathogenesis of WG. Here we review both clinical and experimental data that either indicate or support a role for S. aureus in WG.

Published
2001

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