1. [C-ANCA positive necrotising scleritis and multiple sclerosis compatible with ocular Wegener: treatment with rituximab].
- Author
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Aldasoro-Cáceres V, Aldasoro-Cáceres I, Pérez-Moreiras JV, Murié-Fernández M, and Ibáñez-Bosch R
- Subjects
- Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adult, Brain pathology, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Drug Therapy, Combination, Female, Granulomatosis with Polyangiitis complications, Granulomatosis with Polyangiitis drug therapy, Humans, Magnetic Resonance Imaging, Multiple Sclerosis, Relapsing-Remitting cerebrospinal fluid, Multiple Sclerosis, Relapsing-Remitting diagnosis, Oligoclonal Bands cerebrospinal fluid, Orbital Pseudotumor drug therapy, Prednisone therapeutic use, Rituximab, Sclera transplantation, Scleritis surgery, Antibodies, Antineutrophil Cytoplasmic blood, Antibodies, Monoclonal, Murine-Derived therapeutic use, Granulomatosis with Polyangiitis diagnosis, Immunosuppressive Agents therapeutic use, Multiple Sclerosis, Relapsing-Remitting complications, Orbital Pseudotumor complications, Scleritis etiology
- Abstract
Case Report: A patient diagnosed with necrotizing scleritis, c-ANCA+ an orbital pseudotumour, and possible multiple sclerosis in 2003 was treated with oral cyclophosphamide and steroids with partial response. Between 2005-2010 she suffered self-limited episodes. In 2010 a first scleral transplant was performed with poor outcome. She was treated with rituximab, and a second graft was performed with good results. At 12 months there was no change in magnetic resonance and the second graft healed., Discussion: Wegener's disease with limited involvement of the orbit and/or the eye is a rare condition. The histopathology, blood analysis, symptoms and good response to treatment are the key to its diagnosis., (Copyright © 2011 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.)
- Published
- 2014
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