16 results on '"V. Palermo"'
Search Results
2. Keratin/Polylactic acid/graphene oxide composite nanofibers for drug delivery.
- Author
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Schifino G, Gasparini C, Drudi S, Giannelli M, Sotgiu G, Posati T, Zamboni R, Treossi E, Maccaferri E, Giorgini L, Mazzarro R, Morandi V, Palermo V, Bertoldo M, and Aluigi A
- Subjects
- Keratins chemistry, Polyesters chemistry, Graphite chemistry, Nanofibers chemistry
- Abstract
In this work keratin/poly(lactic acid) (PLA) 50/50 wt blend nanofibers with different loadings of graphene-oxide (GO) were prepared by electrospinning and tested as delivery systems of Rhodamine Blue (RhB), selected as a model of a drug. The effect of GO on the electrospinnability and drug release mechanism and kinetics was investigated. Rheological measurements carried out on the blend solutions revealed unsatisfactory compatibility between keratin and PLA under quiet condition. Accordingly, poor interfacial adhesion between the two phases was observed by SEM analysis of a film prepared by solution casting. On the contrary, keratin chains seem to rearrange under the flux conditions of the electrospinning process thus promoting better interfacial interactions between the two polymers, thereby enhancing their miscibility, which resulted in homogeneous and defect-free nanofibers. The loading of GO into the keratin/PLA solution contributes to increase its viscosity, its shear thinning behavior, and its conductivity. Accordingly, thinner and more homogeneous nanofibers resulted from solutions with a relatively high conductivity coupled with a pronounced shear thinning behavior. FTIR and DSC analyses have underlined, that while the PLA/GO interfacial interactions significantly compete with the PLA/keratin ones, there are no significant effects of GO on the structural organization of keratin in blend with the PLA. However, GO offers several advantages from the application point of view by slightly improving the mechanical properties of the electrospun mats and by slowing down the release of the model drug through the reduction of the matrix swelling., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
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3. Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types.
- Author
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Fusco L, Orecchioni M, Reina G, Bordoni V, Fuoco C, Gurcan C, Guo S, Zoccheddu M, Collino F, Zavan B, Treossi E, Yilmazer A, Palermo V, Bianco A, and Delogu LG
- Subjects
- Humans, Leukocytes, Mononuclear, Monocytes, Single-Cell Analysis, Graphite toxicity, Nanostructures toxicity
- Abstract
Given the wide variety of potential applications of graphene oxide (GO), its consequent release into the environment poses serious concerns on its safety. The future production and exploitation of graphene in the years to come should be guided by its specific chemical-physical characteristics. The unparalleled potential of single-cell mass cytometry (CyTOF) to dissect by high-dimensionality the specific immunological effects of nanomaterials, represents a turning point in nanotoxicology. It helps us to identify the safe graphene in terms of physical-chemical properties and therefore to direct its future safe production. Here we present a high-dimensional study to evaluate two historically indicated as key parameters for the safe exploitation: functionalization and dimension. The role of lateral dimension and the amino-functionalization of GO on their immune impact were here evaluated as synergistic players. To this end, we dissected the effects of GO, characterized by a large or small lateral size (GO 1.32 μm and GO 0.13 μm, respectively), and its amino-functionalized counterpart (GONH
2 1.32 μm and GONH2 0.13 μm, respectively) on fifteen cell types of human primary peripheral blood mononuclear cells (PBMCs). We describe how the smallest later size not only evokes pronounced toxicity on the pool of PBMCs compared to larger GOs but also towards the distinct immune cell subpopulations, in particular on non-classical monocytes, plasmacytoid dendritic cells (pDCs), natural killer cells (NKs) and B cells. The amino-functionalization was able to improve the biocompatibility of classical and non-classical monocytes, pDCs, NKs, and B cells. Detailed single-cell analysis further revealed a complex interaction of all GOs with the immune cells, and in particular monocyte subpopulations, with different potency depending on their physicochemical properties. Overall, by high-dimensional profiling, our study demonstrates that the lateral dimension is an important factor modulating immune cells and specifically monocyte activation, but a proper surface functionalization is the dominant characteristic in its immune effects. In particular, the amino-functionalization can critically modify graphene impact dampening the immune cell activation. Our study can serve as a guide for the future broad production and use of graphene in our everyday life., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
- Full Text
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4. Biodegradation of graphene materials catalyzed by human eosinophil peroxidase.
- Author
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Kurapati R, Martìn C, Palermo V, Nishina Y, and Bianco A
- Subjects
- Catalysis, Eosinophil Peroxidase, Humans, Spectrum Analysis, Raman, Graphite, Nanostructures
- Abstract
Understanding the biodegradability of graphene materials by the action of oxidative enzymes secreted by immune cells is essential for developing applicable biomedical products based on these materials. Herein, we demonstrate the biodegradation of graphene oxide (GO) by recombinant eosinophil peroxidase (EPO) enzyme extracted from human eosinophils in the presence of a low concentration of hydrogen peroxide and NaBr. We compared the degradation capability of the enzyme on three different GO samples containing different degrees of oxygen functional groups on their graphenic lattices. EPO succeeded in degrading the three tested GO samples within 90 h treatment. Raman spectroscopy and transmission electron microscopy analyses provided clear-cut evidence for the biodegradation of GO by EPO catalysis. Our results provide more insight into a better understanding of the biodegradation of graphene materials, helping the design of future biomedical products based on these carbon nanomaterials.
- Published
- 2021
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5. Graphene glial-interfaces: challenges and perspectives.
- Author
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Fabbri R, Saracino E, Treossi E, Zamboni R, Palermo V, and Benfenati V
- Subjects
- Neuroglia, Neurons, Synaptic Transmission, Graphite
- Abstract
Graphene nanosheets are mechanically strong but flexible, electrically conductive and bio-compatible. Thus, due to these unique properties, they are being intensively studied as materials for the next generation of neural interfaces. Most of the literature focused on optimizing the interface between these materials and neurons. However, one of the most common causes of implant failure is the adverse inflammatory reaction of glial cells. These cells are not, as previously considered, just passive and supportive cells, but play a crucial role in the physiology and pathology of the nervous system, and in the interaction with implanted electrodes. Besides providing structural support to neurons, glia are responsible for the modulation of synaptic transmission and control of central and peripheral homeostasis. Accordingly, knowledge on the interaction between glia and biomaterials is essential to develop new implant-based therapies for the treatment of neurological disorders, such as epilepsy, brain tumours, and Alzheimer's and Parkinson's disease. This work provides an overview of the emerging literature on the interaction of graphene-based materials with glial cells, together with a complete description of the different types of glial cells and problems associated with them. We believe that this description will be important for researchers working in materials science and nanotechnology to develop new active materials to interface, measure and stimulate these cells.
- Published
- 2021
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6. Graphene oxide-polysulfone filters for tap water purification, obtained by fast microwave oven treatment.
- Author
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Kovtun A, Zambianchi M, Bettini C, Liscio A, Gazzano M, Corticelli F, Treossi E, Navacchia ML, Palermo V, and Melucci M
- Subjects
- Adsorption, Cost-Benefit Analysis, Materials Testing, Nanoparticles, Organic Chemicals chemistry, Porosity, Wastewater, Water Pollutants, Chemical isolation & purification, X-Ray Diffraction, Graphite chemistry, Microwaves, Nanotechnology methods, Polymers chemistry, Sulfones chemistry, Water Purification methods
- Abstract
The availability of clean, pure water is a major challenge for the future of our society. 2-Dimensional nanosheets of GO seem promising as nanoporous adsorbent or filters for water purification; however, their processing in macroscopic filters is challenging, and their cost vs. standard polymer filters is too high. Here, we describe a novel approach to combine graphene oxide (GO) sheets with commercial polysulfone (PSU) membranes for improved removal of organic contaminants from water. The adsorption physics of contaminants on the PSU-GO composite follows Langmuir and Brunauer-Emmett-Teller (BET) models, with partial swelling and intercalation of molecules in between the GO layers. Such a mechanism, well-known in layered clays, has not been reported previously for graphene or GO. Our approach requires minimal amounts of GO, deposited directly on the surface of the polymer, followed by stabilization using microwaves or heat. The purification efficiency of the PSU-GO composites is significantly improved vs. benchmark commercial PSU, as demonstrated by the removal of two model contaminants, rhodamine B and ofloxacin. The excellent stability of the composite is confirmed by extensive (100 hours) filtration tests in commercial water cartridges.
- Published
- 2019
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7. Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans.
- Author
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Rive C, Reina G, Wagle P, Treossi E, Palermo V, Bianco A, Delogu LG, Rieckher M, and Schumacher B
- Subjects
- Animals, Caenorhabditis elegans immunology, Caenorhabditis elegans metabolism, Immunity, Innate drug effects, Immunity, Innate physiology, MAP Kinase Signaling System drug effects, Nanoparticles adverse effects, Nanoparticles chemistry, Nanostructures adverse effects, Nanostructures chemistry, p38 Mitogen-Activated Protein Kinases metabolism, Caenorhabditis elegans drug effects, Graphite adverse effects, Graphite chemistry
- Abstract
Graphene oxide (GO) holds high promise for diagnostic and therapeutic applications in nanomedicine but reportedly displays immunotoxicity, underlining the need for developing functionalized GO with improved biocompatibility. This study describes adverse effects of GO and amino-functionalized GO (GONH
2 ) during Caenorhabditis elegans development and ageing upon acute or chronic exposure. Chronic GO treatment throughout the C. elegans development causes decreased fecundity and a reduction of animal size, while acute treatment does not lead to any measurable physiological decline. However, RNA-Sequencing data reveal that acute GO exposure induces innate immune gene expression. The p38 MAP kinase, PMK-1, which is a well-established master regulator of innate immunity, protects C. elegans from chronic GO toxicity, as pmk-1 mutants show reduced tissue-functionality and facultative vivipary. In a direct comparison, GONH2 exposure does not cause detrimental effects in the wild type or in pmk-1 mutants, and the innate immune response is considerably less pronounced. This work establishes enhanced biocompatibility of amino-functionalized GO in a whole-organism, emphasizing its potential as a biomedical nanomaterial., (© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)- Published
- 2019
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8. An Evaluation of Graphene as a Multi-Functional Heating Element for Biomedical Applications.
- Author
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Anagnostopoulos G, Treossi E, Parthenios J, Papagelis K, Palermo V, and Galiotis C
- Subjects
- Heating, Equipment and Supplies, Graphite, Hot Temperature
- Abstract
Graphene has been found to be an excellent heat-conductor due to the high speed of acoustic phonons in its lattice. In this work, we examine in depth a commercial graphene-based waist protector which uses graphene as a heating element. By employing thermal imaging in tandem with Raman microscopy, the thermal characteristics and performance of this device is fully assessed. It will be shown that no pronounced variation in its function is observed up to 3 hours of continuous operation and that the device seems to work effectively as an IR emitter at low power consumption. Temperature fluctuations, associated with a decrease of its electrical resistance are observed after 12 hours uptime and a temperature difference of 15 °C was recorded after 5 days of uninterrupted operation. These effects are thought to be due to the loss of graphene/polymer adhesion resulting from thermal fatigue. Overall, it is demonstrated that graphene can indeed be incorporated as an effective and operational thermal heating system in similar biomedical devices.
- Published
- 2018
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9. Uptake of label-free graphene oxide by Caco-2 cells is dependent on the cell differentiation status.
- Author
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Kucki M, Diener L, Bohmer N, Hirsch C, Krug HF, Palermo V, and Wick P
- Subjects
- Caco-2 Cells, Cell Differentiation, Epithelial Cells cytology, Epithelial Cells metabolism, Epithelial Cells ultrastructure, Graphite analysis, Humans, Intestinal Mucosa ultrastructure, Microvilli metabolism, Microvilli ultrastructure, Nanostructures analysis, Nanostructures ultrastructure, Oxides analysis, Graphite metabolism, Intestinal Mucosa cytology, Intestinal Mucosa metabolism, Oxides metabolism
- Abstract
Background: Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake of GRM by human intestinal cells after unintended ingestion. Therefore the aim of our study was to investigate the interaction of label-free graphene oxide (GO) with the intestinal cell line Caco-2 in vitro and to shed light on the influence of the cell phenotype given by the differentiation status on cellular uptake behaviour., Results: Internalisation of two label-free GOs with different lateral size and thickness by undifferentiated and differentiated Caco-2 cells was analysed by scanning electron microscopy and transmission electron microscopy. Semi-quantification of cells associated with GRM was performed by flow cytometry. Undifferentiated Caco-2 cells showed significant amounts of cell-associated GRM, whereas differentiated Caco-2 cells exhibited low adhesion of GO sheets. Transmission electron microscopy analysis revealed internalisation of both applied GO (small and large) by undifferentiated Caco-2 cells. Even large GO sheets with lateral dimensions up to 10 µm, were found internalised by undifferentiated cells, presumably by macropinocytosis. In contrast, no GO uptake could be found for differentiated Caco-2 cells exhibiting an enterocyte-like morphology with apical brush border., Conclusions: Our results show that the internalisation of GO is highly dependent on the cell differentiation status of human intestinal cells. During differentiation Caco-2 cells undergo intense phenotypic changes which lead to a dramatic decrease in GRM internalisation. The results support the hypothesis that the cell surface topography of differentiated Caco-2 cells given by the brush border leads to low adhesion of GO sheets and sterical hindrance for material uptake. In addition, the mechanical properties of GRM, especially flexibility of the sheets, seem to be an important factor for internalisation of large GO sheets by epithelial cells. Our results highlight the importance of the choice of the in vitro model to enable better in vitro-in vivo translation.
- Published
- 2017
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10. Interaction of graphene-related materials with human intestinal cells: an in vitro approach.
- Author
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Kucki M, Rupper P, Sarrieu C, Melucci M, Treossi E, Schwarz A, León V, Kraegeloh A, Flahaut E, Vázquez E, Palermo V, and Wick P
- Subjects
- Caco-2 Cells, Cell Survival drug effects, Graphite toxicity, Humans, Nanostructures toxicity, Nanostructures ultrastructure, Nanotechnology, Reactive Oxygen Species metabolism, Enterocytes drug effects, Enterocytes metabolism, Enterocytes pathology, Graphite chemistry, Nanostructures chemistry
- Abstract
Graphene-related materials (GRM) inherit unique combinations of physicochemical properties which offer a high potential for technological as well as biomedical applications. It is not clear which physicochemical properties are the most relevant factors influencing the behavior of GRM in complex biological environments. In this study we have focused on the interaction of GRM, especially graphene oxide (GO), and Caco-2 cells in vitro. We mimiked stomach transition by acid-treatment of two representative GRM followed by analysis of their physicochemical properties. No significant changes in the material properties or cell viability of exposed Caco-2 cells in respect to untreated GRM could be detected. Furthermore, we explored the interaction of four different GO and Caco-2 cells to identify relevant physicochemical properties for the establishment of a material property-biological response relationship. Despite close interaction with the cell surface and the formation of reactive oxygen species (ROS), no acute toxicity was found for any of the applied GO (concentration range 0-80 μg ml(-1)) after 24 h and 48 h exposure. Graphene nanoplatelet aggregates led to low acute toxicity at high concentrations, indicating that aggregation, the number of layers or the C/O ratio have a more pronounced effect on the cell viability than the lateral size alone.
- Published
- 2016
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11. Supramolecular self-assembly of graphene oxide and metal nanoparticles into stacked multilayers by means of a multitasking protein ring.
- Author
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Ardini M, Golia G, Passaretti P, Cimini A, Pitari G, Giansanti F, Di Leandro L, Ottaviano L, Perrozzi F, Santucci S, Morandi V, Ortolani L, Christian M, Treossi E, Palermo V, Angelucci F, and Ippoliti R
- Subjects
- Adsorption, Amino Acids chemistry, Animals, Cysteine chemistry, Gold chemistry, Hydrogen-Ion Concentration, Ions, Methionine chemistry, Microscopy, Atomic Force, Microscopy, Electron, Scanning, Microscopy, Electron, Scanning Transmission, Microscopy, Electron, Transmission, Oxidation-Reduction, Palladium chemistry, Peroxiredoxins chemistry, Schistosoma mansoni, Spectrophotometry, Ultraviolet, Sulfur chemistry, Temperature, Thioglycolates chemistry, Graphite chemistry, Metal Nanoparticles chemistry, Oxides chemistry, Protein Engineering methods
- Abstract
Graphene oxide (GO) is rapidly emerging worldwide as a breakthrough precursor material for next-generation devices. However, this requires the transition of its two-dimensional layered structure into more accessible three-dimensional (3D) arrays. Peroxiredoxins (Prx) are a family of multitasking redox enzymes, self-assembling into ring-like architectures. Taking advantage of both their symmetric structure and function, 3D reduced GO-based composites are hereby built up. Results reveal that the "double-faced" Prx rings can adhere flat on single GO layers and partially reduce them by their sulfur-containing amino acids, driving their stacking into 3D multi-layer reduced GO-Prx composites. This process occurs in aqueous solution at a very low GO concentration, i.e. 0.2 mg ml(-1). Further, protein engineering allows the Prx ring to be enriched with metal binding sites inside its lumen. This feature is exploited to both capture presynthesized gold nanoparticles and grow in situ palladium nanoparticles paving the way to straightforward and "green" routes to 3D reduced GO-metal composite materials.
- Published
- 2016
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12. Dispersibility-Dependent Biodegradation of Graphene Oxide by Myeloperoxidase.
- Author
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Kurapati R, Russier J, Squillaci MA, Treossi E, Ménard-Moyon C, Del Rio-Castillo AE, Vazquez E, Samorì P, Palermo V, and Bianco A
- Subjects
- Biodegradation, Environmental, Humans, Particle Size, Spectrum Analysis, Raman, Graphite chemistry, Oxides chemistry, Peroxidase metabolism
- Abstract
Understanding human health risk associated with the rapidly emerging graphene-based nanomaterials represents a great challenge because of the diversity of applications and the wide range of possible ways of exposure to this type of materials. Herein, the biodegradation of graphene oxide (GO) sheets is reported by using myeloperoxidase (hMPO) derived from human neutrophils in the presence of a low concentration of hydrogen peroxide. The degradation capability of the enzyme on three different GO samples containing different degree of oxidation on their graphenic lattice, leading to a variable dispersibility in aqueous media is compared. hMPO fails in degrading the most aggregated GO, but succeeds to completely metabolize highly dispersed GO samples. The spectroscopy and microscopy analyses provide unambiguous evidence for the key roles played by hydrophilicity, negative surface charge, and colloidal stability of the aqueous GO in their biodegradation by hMPO catalysis., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2015
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13. Playing peekaboo with graphene oxide: a scanning electrochemical microscopy investigation.
- Author
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Rapino S, Treossi E, Palermo V, Marcaccio M, Paolucci F, and Zerbetto F
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- Gold chemistry, Kinetics, Oxides chemistry, Silicon Compounds chemistry, Graphite chemistry, Microscopy, Electrochemical, Scanning
- Abstract
Scanning electrochemical microscopy (SECM) can image graphene oxide (GO) flakes on insulating and conducting substrates. The contrast between GO and the substrate is controlled by the electrostatic interactions that are established between the charges of the molecular redox mediator and the charges present in the sheet/substrate. SECM also allows quantitative measurement - at the nano/microscale - of the charge transfer kinetics between single monolayer sheets and agent molecules.
- Published
- 2014
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14. Flake size-dependent cyto and genotoxic evaluation of graphene oxide on in vitro A549, CaCo2 and vero cell lines.
- Author
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De Marzi L, Ottaviano L, Perrozzi F, Nardone M, Santucci S, De Lapuente J, Borras M, Treossi E, Palermo V, and Poma A
- Subjects
- Animals, Caco-2 Cells, Cell Survival drug effects, Chlorocebus aethiops, Graphite chemistry, Humans, Microscopy, Electron, Scanning, Particle Size, Spectrum Analysis, Raman, Vero Cells, DNA Damage, Graphite toxicity
- Abstract
This study was carried out by varying both graphene oxide (GO) concentration (10 μg/mL, 50 μg/mL, 100 μg/mL) and flakes sizes of 1320 nm and 130 nm. Characterization by scanning electron microscopy and Raman spectroscopy demonstrate that the area of GO flakes varies of one order of magnitude but their chemical structure remains unmodified. A 24-h cytotoxicity test showed, for A549, a loss in the viability, while the test exhibits overall a positive increase in the viability for CaCo2 and Vero. A 24-h comet assay shows a marked GO genotoxicity: for micrometer-sized GO flakes the genotoxicity is in positive correlation with the concentration, while for nanometer-sized GO flakes there was a high degree of genotoxicity at the lowest concentration tested.
- Published
- 2014
15. Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells.
- Author
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Russier J, Treossi E, Scarsi A, Perrozzi F, Dumortier H, Ottaviano L, Meneghetti M, Palermo V, and Bianco A
- Subjects
- Animals, Cell Survival drug effects, Cells, Cultured, Cytokines metabolism, Graphite toxicity, Humans, Macrophages drug effects, Macrophages metabolism, Mice, Monocytes cytology, Oxidative Stress drug effects, Oxides chemistry, Reactive Oxygen Species metabolism, Graphite chemistry, Macrophages cytology
- Abstract
Graphene oxide (GO) is attracting an ever-growing interest in different fields and applications. Not much is known about the possible impact of GO sheet lateral dimensions on their effects in vitro, especially on human primary cells. In an attempt to address this issue, we present a study to evaluate, how highly soluble 2-dimensional GO constituted of large or small flakes affects human monocyte derived macrophages (hMDM). For this purpose, the lateral size of GO was tuned using sonication and three samples were obtained. The non sonicated one presented large flakes (~1.32 μm) while sonication for 2 and 26 hours generated small (~0.27 μm) and very small (~0.13 μm) sheets of GO, respectively. Cell studies were then conducted to evaluate the cytotoxicity, the oxidative stress induction, the activation potential and the pro-inflammatory effects of these different types of GO at increasing concentrations. In comparison, the same experiments were run on murine intraperitoneal macrophages (mIPM). The interaction between GO and cells was further examined by TEM and Raman spectroscopy. Our data revealed that the GO sheet size had a significant impact on different cellular parameters (i.e. cellular viability, ROS generation, and cellular activation). Indeed, the more the lateral dimensions of GO were reduced, the higher were the cellular internalization and the effects on cellular functionality. Our data also revealed a particular interaction of GO flakes with the cellular membrane. In fact, a GO mask due to the parallel arrangement of the graphene sheets on the cellular surface was observed. Considering the mask effect, we have hypothesized that this particular contact between GO sheets and the cell membrane could either promote their internalization or isolate cells from their environment, thus possibly accounting for the following impact on cellular parameters.
- Published
- 2013
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16. Processing of giant graphene molecules by soft-landing mass spectrometry.
- Author
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Räder HJ, Rouhanipour A, Talarico AM, Palermo V, Samorì P, and Müllen K
- Subjects
- Capillaries, Catalysis, Image Processing, Computer-Assisted, Ions, Manufactured Materials, Microscopy, Atomic Force, Microscopy, Electron, Transmission, Models, Chemical, Models, Molecular, Nanotechnology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Surface Properties, Temperature, Graphite chemistry, Mass Spectrometry methods
- Abstract
The processability of giant (macro)molecules into ultrapure and highly ordered structures at surfaces is of fundamental importance for studying chemical, physical and biological phenomena, as well as their exploitation as active units in the fabrication of hybrid devices. The possibility of handling larger and larger molecules provides access to increasingly complex functions. Unfortunately, larger molecules commonly imply lower processability due to either their low solubility in liquid media or the occurrence of thermal cracking during vacuum sublimation. The search for novel strategies to process and characterize giant building blocks is therefore a crucial goal in materials science. Here we describe a new general route to process, at surfaces, extraordinarily large molecules, that is, synthetic nanographenes, into ultrapure crystalline architectures. Our method relies on the soft-landing of ions generated by solvent-free matrix-assisted laser desorption/ionization (MALDI). The nanographenes are transferred to the gas phase, purified and adsorbed at surfaces. Scanning tunnelling microscopy reveals the formation of ordered nanoscale semiconducting supramolecular architectures. The unique flexibility of this approach allows the growth of ultrapure crystalline films of various systems, including organic, inorganic and biological molecules, and therefore it can be of interest for technological applications in the fields of electronics, (bio)catalysis and nanomedicine.
- Published
- 2006
- Full Text
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