1. The sensitizing capacity of coumarins (I).
- Author
-
Hausen, B. M. and Schmieder, M.
- Subjects
- *
CONTACT dermatitis , *GUINEA pigs , *COUMARINS , *PERFUMES , *COSMETICS , *SKIN inflammation - Abstract
10 coumarins used in perfumery, cosmetics and ointments have been investigated by 2 different methods to determine their sensitizing capacity. Only1 of the compounds, 4-methyl-esculetin, which serves as a sunscreen agent, was found to be a weak sensitizer. All other coumarins were negative. It is assumed that this dihydroxycoumarin becomes a sensitizer when it is enzymically oxidized to the corresponding orthoquinone in the skin. [ABSTRACT FROM AUTHOR]
- Published
- 1986
- Full Text
- View/download PDF