1. Predictors of Gleason score upgrading in a large African-American population
- Author
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Krishnan Venkatesan, Tim Large, Hanaa Nissim, Sherod Haynes, John J. Lynch, Reza Ghasemian, Mohan Verghese, Kevin McGeagh, Daniel Marchalik, Jonathan Hwang, Gaurav Bandi, Keith Kowalczyk, Anup Vora, Jenny Aronica, and Andrew Harbin
- Subjects
Image-Guided Biopsy ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Population ,Adenocarcinoma ,Risk Assessment ,Body Mass Index ,Prostate cancer ,Risk Factors ,Internal medicine ,Biopsy ,medicine ,Humans ,education ,Aged ,Prostatectomy ,Gynecology ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Prostate ,Prostatic Neoplasms ,Cancer ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,Black or African American ,Prostate-specific antigen ,Nephrology ,Prostate surgery ,Neoplasm Grading ,business ,Body mass index - Abstract
Gleason score from biopsy specimens is important for prostate cancer (PCa) risk stratification and influences treatment decisions. Gleason score upgrading (GSU) between biopsy and surgical pathology specimens has been reported as high as 50 % and presents a challenge in counseling low-risk patients. While recent studies have investigated predictors of GSU, populations in these studies have been largely Caucasian. We report our analysis of predictors of GSU in a large urban African-American population. A total of 959 patients with D’Amico low-risk prostate cancer underwent radical prostatectomy at Georgetown University or Washington Hospital Center between January 2005 and July 2012. Race, age, PSA, body mass index (BMI), cancer of the prostate risk assessment (CAPRA) score, and transrectal ultrasound (TRUS) biopsy characteristics (percent of biopsy cores showing adenocarcinoma, highest percent of biopsy core involved with cancer, and measured TRUS prostate volume) were analyzed with both univariate and multivariate analyses to identify significant predictors of GSU while controlling for clinical parameters. Of the 959 cases, 288 (30.0 %) were upgraded on final pathologic specimen with approximately 38 % (133/355) of African-American patients experiencing GSU. BMI (P = 0.02), percent positive biopsy cores (P
- Published
- 2013
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