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These days, cyber-criminals target humans rather than machines since they try to accomplish their malicious intentions by exploiting the weaknesses of end users. Thus, human vulnerabilities pose a serious threat to the security and integrity of computer systems and data. The human tendency to trust and help others, as well as personal, social, and cultural characteristics, are indicative of the level of susceptibility that one may exhibit towards certain attack types and deception strategies. This work aims to investigate the factors that affect human susceptibility by studying the existing literature related to this subject. The objective is also to explore and describe state of the art human vulnerability assessment models, current prevention, and mitigation approaches regarding user susceptibility, as well as educational and awareness raising training strategies. Following the review of the literature, several conclusions are reached. Among them, Human Vulnerability Assessment has been included in various frameworks aiming to assess the cyber security capacity of organizations, but it concerns a one time assessment rather than a continuous practice. Moreover, human maliciousness is still neglected from current Human Vulnerability Assessment frameworks; thus, insider threat actors evade identification, which may lead to an increased cyber security risk. Finally, this work proposes a user susceptibility profile according to the factors stemming from our research., Comment: 39 pages, 4 figures, Submitted for Review to Association for Computing Machinery (ACM) - Computing Surveys, fixed author's name misspelling