In low‐ and middle‐income countries, medications are routinely prescribed for maternal and foetal well‐being. The objective of this study was to assess the adherence with routine haematinics and multivitamins among pregnant women in a lower‐middle‐income country, Ghana. A questionnaire was used to collect data from 350 pregnant women utilizing the antenatal clinic of the Tamale Teaching Hospital. Adherence was about 63% for folic acid, 63% for ferrous sulphate and 58% for multivitamins. For folic acid, younger age, secondary and tertiary education had about 31%, 46% and 41%, respectively, less likelihood of non‐adherence. Second trimester of pregnancy was associated with two times more likelihood of adherence with folic acid. For ferrous sulphate, younger age had about 30% less likelihood of non‐adherence, and second trimester linked to twice more likelihood of adherence. Secondary education had about 40% less likelihood of non‐adherence with multivitamins. More of those who adhered with folic acid (89%), ferrous sulphate (89%) and multivitamins (91%) had their haemoglobin level increased. Adherence with routine haematinics was adequate; age, education and trimester of pregnancy predicted folic acid and ferrous sulphate adherence. Education predicted adherence with multivitamins. Adherence was associated with change in level of haemoglobin during antenatal visits. [ABSTRACT FROM AUTHOR]