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C. Guo et al. (Hearing phenotypes of patients with hearing loss homozygous for the GJB2 c.235delc mutation) investigate the hearing phenotypes of 244 Chinese patients with hearing loss associated with the homozygous c.235delC mutation of GJB2 and report a significant variation in their binaural hearing loss phenotypes, including severity of hearing loss, and audiogram shapes. Although SNHL is induced by various factors through different approaches and mechanisms, the major cause for SNHL is irreversible loss of either inner ear hair cells (HCs) or degeneration of spiral ganglion neurons (SGNs). [Extracted from the article]