1. Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia.
- Author
-
Lublin H, Gerlach J, Hagert U, Meidahl B, Mølbjerg C, Pedersen V, Rendtorff C, and Tolvanen E
- Subjects
- Adult, Aged, Clopenthixol adverse effects, Double-Blind Method, Female, Haloperidol adverse effects, Humans, Male, Middle Aged, Parkinson Disease, Secondary chemically induced, Psychiatric Status Rating Scales, Psychotic Disorders complications, Clopenthixol therapeutic use, Dyskinesia, Drug-Induced drug therapy, Haloperidol therapeutic use
- Abstract
Animal data suggest that a D1 antagonistic component in neuroleptic drugs counteracts development of dopamine supersensitivity and of tolerance to cataleptic effect. This has led to the hypothesis that neuroleptics with D1 antagonistic activity should cause a better suppression of tardive dyskinesia (TD) and less rebound aggravation after withdrawal than pure D2 antagonists. In this study the effect of zuclopenthixol (mixed D1/D2 antagonist) and haloperidol (D2 antagonist) was evaluated in chronic psychotic patients with TD. Fifteen patients completed a randomized crossover study with blind evaluation of TD and parkinsonism. The test medications, haloperidol and zuclopenthixol, caused a significant suppression of TD and a significant increase of parkinsonism. No significant differences between haloperidol and zuclopenthixol were observed. No TD aggravation was seen. The lack of differences between the mixed D1/D2 antagonist and a D2 antagonist suggest that tolerance and DA supersensitivity play no or a minor role for development of TD.
- Published
- 1991
- Full Text
- View/download PDF