1. Prognostic biomarkers in patients with human immunodeficiency virus‐positive disease with head and neck squamous cell carcinoma
- Author
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Zhang, Hongzheng, Kim, Sungjin, Chen, Zhengjia, Nannapaneni, Sreenivas, Chen, Amy Y, Moore, Charles E, Sica, Gabriel, Mosunjac, Marina, Nguyen, Minh Ly T, D'Souza, Gypsyamber, Carey, Thomas E, Peterson, Lisa A, McHugh, Jonathan B, Graham, Martin, Komarck, Christine M, Wolf, Gregory T, Walline, Heather M, Bellile, Emily, Riddell, James, Pai, Sara I, Sidransky, David, Westra, William H, William, William N, Lee, J Jack, El‐Naggar, Adel K, Ferris, Robert L, Seethala, Raja, Grandis, Jennifer R, Chen, Zhuo Georgia, Saba, Nabil F, Shin, Dong M, and consortium, on behalf of the Head and Neck Cancer SPORE HIV supplement
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Dental/Oral and Craniofacial Disease ,HIV/AIDS ,Rare Diseases ,Clinical Research ,Prevention ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Biomarkers ,Tumor ,Carcinoma ,Squamous Cell ,Case-Control Studies ,Cause of Death ,Combined Modality Therapy ,Disease-Free Survival ,Female ,HIV Infections ,HIV Seropositivity ,Head and Neck Neoplasms ,Humans ,Kaplan-Meier Estimate ,Logistic Models ,Male ,Middle Aged ,Multivariate Analysis ,Prognosis ,Proportional Hazards Models ,Retrospective Studies ,Risk Assessment ,Squamous Cell Carcinoma of Head and Neck ,Survival Analysis ,Transforming Growth Factor beta1 ,Treatment Outcome ,biomarkers ,head and neck cancer ,human immunodeficiency virus ,prognosis ,survival ,Head and Neck Cancer SPORE HIV supplement consortium ,Dentistry ,Otorhinolaryngology ,Clinical sciences - Abstract
BackgroundWe examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer).MethodsTissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables.ResultsExpression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIV-positive head and neck cancer, laryngeal disease site (P = .003) and Clavien-Dindo classification IV (CD4) counts
- Published
- 2017