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Author(s): Zeynep Kemer Aktas [sup.1] , Gülsah Kaya Aksoy [sup.2] , Havva Serap Toru [sup.3] , Mustafa Koyun [sup.2] , Elif Çomak [sup.2] , Elif Güler [sup.4] , Mehmet Emin [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Department of Pediatric Nephrology, Faculty of Medicine, Akdeniz University, [...]

Author(s): Zeynep Kemer Aktas [sup.1] , Gülsah Kaya Aksoy [sup.2] , Havva Serap Toru [sup.3] , Mustafa Koyun [sup.2] , Elif Çomak [sup.2] , Elif Güler [sup.4] , Mehmet Emin [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Adil Boz [sup.2] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Department of Pediatric Nehrology, Faculty [...]

Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G. Methods Sixty pediatric patients with C3G from 21 referral centers in Turkey were included in this retrospective study. Patients were categorized according to CKD stage at last visit as CKD5 or non-CKD5. Demographic data, clinicopathologic findings, treatment, and outcome data were compared and possible risk factors for CKD5 progression determined using Cox proportional hazards model. Results Mean age at diagnosis was 10.6 ± 3.0 years and follow-up time 48.3 ± 36.3 months. Almost half the patients had gross hematuria and hypertension at diagnosis. Nephritic-nephrotic syndrome was the commonest presenting feature (41.6%) and 1/5 of patients presented with nephrotic syndrome. Membranoproliferative glomerulonephritis was the leading injury pattern, while 40 patients had only C3 staining. Patients with DDD had significantly lower baseline serum albumin compared with C3GN. Eighteen patients received eculizumab. Clinical remission was achieved in 68.3%. At last follow-up, 10 patients (16.6%) developed CKD5: they had lower baseline eGFR and albumin and higher frequency of nephrotic syndrome and dialysis requirement than non-CKD5 patients. Lower serum albumin and eGFR at diagnosis were independent predictors for CKD5 development. Conclusions Children with C3G who have impaired kidney function and hypoalbuminemia at diagnosis should be carefully monitored for risk of progression to CKD5. Graphical abstract, Author(s): Ayse Seda Pinarbasi [sup.1] , Ismail Dursun [sup.1] , Ibrahim Gokce [sup.2] , Elif Çomak [sup.3] , Seha Saygili [sup.4] , Meral Torun Bayram [sup.5] , Osman Donmez [sup.6] [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Department of Pediatric Nephrology, Faculty of Medicine, Akdeniz University, [...]

Author(s): Mustafa Koyun [sup.1] , Mustafa Gökhan Ertosun [sup.2] , Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Faculty of Medicine, Department [...]

Author(s): Mustafa Koyun [sup.1] , Mustafa Gökhan Ertosun [sup.2] , Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Faculty of Medicine, Department [...]

Background Although orthostatic proteinuria (OP) is the most common cause of childhood proteinuria, excluding transient proteinuria, data regarding prevalence and long-term prognosis are limited. We aimed to determine prevalence of OP in healthy schoolchildren evaluating relationships with age, gender and body mass index, and determine follow-up. Methods A total of 1701 healthy children aged 6-15 years were selected using a population-based, stratified, cluster-sampling method; and random urine samples were taken. For proteinuria [greater than or equal to] 1+ in first urine samples, second and third random samples were taken at least 2 weeks apart to exclude transient proteinuria. For continuing proteinuria after third samples, first morning urine samples were collected. Cases where proteinuria was not detected in first morning urine samples were diagnosed as OP. Results Sixty-four of 1701 children (3.7%) had proteinuria on first random urine samples. After second and third urine samples, proteinuria persisted in only 16 (0.94%). OP was detected in 11 (0.65%). Prevalence of OP tended to decrease with increasing BMI, though not statistically significant. All 7 cases with OP who were re-evaluated later, had no proteinuria 3 years after diagnosis. Conclusions Prevalence of OP in our study was lower than the literature. At least three random urine samples should be taken to exclude transient proteinuria in an asymptomatic child/adolescent before making a diagnosis of OP using first morning urine samples. OP is a benign condition and resolves spontaneously in most cases. Underweight children had a tendency for OP compared with overweight and obese children; however, further studies with larger number of patients are needed., Author(s): Zümrüt Arslan [sup.1] , Mustafa Koyun [sup.2] , Hakan Erengin [sup.3] , Halide Akbas [sup.4] , Gülsah Kaya Aksoy [sup.2] , Elif Çomak [sup.2] , Sema Akman [sup.2] Author [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Adil Boz [sup.2] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Department of Pediatric Nehrology, Faculty [...]

Author(s): Mustafa Koyun [sup.1] , Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (1) grid.29906.34, Department of Pediatrics, Division of Pediatric Nephrology, School of [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Bahar Akkaya [sup.2] , Mustafa Koyun [sup.1] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]

Author(s): Mustafa Koyun [sup.1] , Muhammet Sancaktar [sup.1] , Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Ayla Kaçar [sup.1] , Mehtap Adar [sup.1] , Afig Berdeli [sup.2] , [...]

Author(s): Mustafa Koyun [sup.1] , Muhammet Sancaktar [sup.1] , Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Ayla Kaçar [sup.1] , Mehtap Adar [sup.1] , Afig Berdeli [sup.2] , [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Cansu Mutlu [sup.2] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Cansu Mutlu [sup.2] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]

Author(s): Gulsah Kaya Aksoy [sup.1] , Atilla Gemici [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Atilla Gemici [sup.1] , Mustafa Koyun [sup.1] , Elif Çomak [sup.1] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]

Author(s): Gülsah Kaya Aksoy [sup.1] , Elif Çomak [sup.1] , Bahar Akkaya [sup.2] , Mustafa Koyun [sup.1] , Sema Akman [sup.1] Author Affiliations: (Aff1) 0000 0001 0428 6825, grid.29906.34, Department [...]