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18 results on '"Vestbo, J"'

1. Adherence to inhaled therapy, mortality and hospital admission in COPD

Author

Vestbo, J., Anderson, J.A., Calverley, P.M.A., Celli, B., Ferguson, G.T., Jenkins, C., Knobil, K., Willits, L.R., Yates, J.C., and Jones, P.W.

Subjects
Lung diseases, Obstructive -- Care and treatment, Lung diseases, Obstructive -- Patient outcomes, Lung diseases, Obstructive -- Research, Aerosol therapy -- Patient outcomes, Aerosol therapy -- Research, Mortality -- United Kingdom, Mortality -- Demographic aspects, Mortality -- Research, Patient compliance -- Research, Hospitals -- Admission and discharge, Hospitals -- Research, Health
Published
2009

3. Association analysis identifies TLR7 ad TLR8 as novel risk genes in asthma and related disorders

Author

Moller-Larsen, S., Nyegaard, M., Haagerup, A., Vestbo, J., Kruse, T.A., and Borglum, A.D.

Subjects
Asthma -- Genetic aspects, Asthma -- Risk factors, Asthma -- Research, Cell receptors -- Physiological aspects, Cell receptors -- Genetic aspects, Cell receptors -- Research, Allergic reaction -- Genetic aspects, Allergic reaction -- Risk factors, Allergic reaction -- Research, Allergy -- Genetic aspects, Allergy -- Risk factors, Allergy -- Research, Immune response -- Research, Health
Published
2008

7. Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease

Author

Sin, D.D., Wu, L., Anderson, J.A., Anthonisen, N.R., Buist, A.S., Burge, P.S., Calverley, P.M., Connett, J.E., Lindmark, B., Pauwels, R.A., Postma, D.S., Soriano, J.B., Szafranski, W., and Vestbo, J.

Subjects
Lung diseases, Obstructive -- Care and treatment, Corticosteroids -- Patient outcomes, Corticosteroids -- Research, Inhalers -- Patient outcomes, Mortality -- Evaluation, Health
Published
2005

9. Smoking reduction, smoking cessation, and incidence of fatal and non-fatal myocardial infarction in Denmark 1976-1998: a pooled cohort study. (Public Health Policy and Practice)

Author

Godtfredsen, N.S., Osler, M., Vestbo, J., Andersen, I., and Prescott, E.

Subjects
Heart attack -- Risk factors -- Causes of, Smoking cessation programs -- Health aspects, Smoking -- Health aspects -- Risk factors, Health, Social sciences, Risk factors, Health aspects, Causes of
Abstract

Objective: To analyse the effects of smoking reduction and smoking cessation on incidence of myocardial infarction after adjustment for established cardiovascular risk factors. Design: Prospective cohort study with record linkage [...]

Published
2003

10. Risk of hospital admission for COPD following smoking cessation and reduction: a Danish population study. (Original Article)

Author

Godtfredsen, N.S., Vestbo, J., Osler, M., and Prescott, E.

Subjects
Hospital utilization -- Demographic aspects -- Health aspects, Lung diseases, Obstructive -- Risk factors, Ex-smokers -- Health aspects, Health, Risk factors, Demographic aspects, Health aspects
Abstract

Background: Little is known about the effects of changes in smoking habits on the subsequent risk of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate [...]

Published
2002

12. Persistent systemic inflammation and symptoms of depression among patients with COPD in the ECLIPSE cohort

Author

Janssen, D.J.A., Mullerova, H., Agusti, A., Yates, J.C., Tal-Singer, R., Rennard, S.I., Vestbo, J., Eclipse Investigators, the, Wouters, E.F.M., RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, Family Medicine, RS: CAPHRI - Asthma and COPD, and Pulmonologie

Subjects
Male, Systemic inflammation, Antidepressive Agents/therapeutic use, Comorbidities, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Depression/drug therapy, Psychological symptoms, Depressive Disorder/drug therapy, ANXIETY, Disease, Chronic, Depression (differential diagnoses), PSYCHOLOGICAL DISTRESS, ASSOCIATIONS, COPD, PERSONALITY, Depression, Confounding, Pulmonary, Middle Aged, United States/epidemiology, Antidepressive Agents, Europe, medicine.anatomical_structure, Quartile, Cohort, Female, HEALTH, medicine.symptom, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pulmonary Disease, Chronic Obstructive/complications, Chronic Obstructive Pulmonary Disease, BIOMARKERS, OBSTRUCTIVE PULMONARY-DISEASE, Europe/epidemiology, Internal medicine, White blood cell, medicine, Humans, DYSPNEA, Aged, Inflammation, Psychiatric Status Rating Scales, Depressive Disorder, business.industry, Depressive disorder, Obstructive, Inflammation/epidemiology, medicine.disease, United States, BODY-MASS INDEX, Physical therapy, GENDER, business, Body mass index, Biomarkers, Follow-Up Studies
Abstract

Background: Depression is highly prevalent among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship of depression with systemic inflammation in COPD remains unknown. The objective of this observational study was to compare depression scores at baseline and after 36 months follow-up between COPD patients with persistent systemic inflammation (PSI) and never inflamed patients (NI) in the ECLIPSE cohort. Methods: The ECLIPSE study included 2164 COPD patients. Parameters assessed at baseline and at 36 months follow-up included: demographics, clinical characteristics and symptoms of depression (Center for Epidemiologic Studies of Depression, CES-D). Patients classified as NI had zero and patients with PSI had >= 2 inflammatory biomarkers (white blood cell count, hsCRP, IL-6, and fibrinogen) in the upper quartile, at baseline and 12 months later. Findings: 350 patients (29.1%) were NI and 131 patients (10.9%) had PSI. At baseline, mean CES-D score was higher in patients with PSI than in NI patients (11.7 (8.6) vs. 9.2 (8.9) points, p = 0.01). Differences were not confirmed after adjustment for possible confounders (13 (95% CI) = 0.02 (-3.87 to 15.29), adjusted p = 0.98). At 36 months follow-up, CES-D scores were comparable in PSI and NI patients (12.2 (9.3) vs. 10.5 (9.0) points, p = 0.08) as were their temporal changes (0.5 (8.3) vs. 1.3 (7.9) points, p = 0.30). Conclusion: The ECLIPSE study does not support a strong relationship between PSI and symptoms of depression at baseline and after 36 months follow-up in COPD. Funding: The study was sponsored by GlaxoSmithKline. (C) 2014 Elsevier Ltd. All rights reserved. SummaryBackground Depression is highly prevalent among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship of depression with systemic inflammation in COPD remains unknown. The objective of this observational study was to compare depression scores at baseline and after 36 months follow-up between COPD patients with persistent systemic inflammation (PSI) and never inflamed patients (NI) in the ECLIPSE cohort. Methods The ECLIPSE study included 2164 COPD patients. Parameters assessed at baseline and at 36 months follow-up included: demographics, clinical characteristics and symptoms of depression (Center for Epidemiologic Studies of Depression, CES-D). Patients classified as NI had zero and patients with PSI had ≥2 inflammatory biomarkers (white blood cell count, hsCRP, IL-6, and fibrinogen) in the upper quartile, at baseline and 12 months later. Findings 350 patients (29.1%) were NI and 131 patients (10.9%) had PSI. At baseline, mean CES-D score was higher in patients with PSI than in NI patients (11.7 (8.6) vs. 9.2 (8.9) points, p = 0.01). Differences were not confirmed after adjustment for possible confounders (β (95% CI) = 0.02 (-3.87 to 15.29), adjusted p = 0.98). At 36 months follow-up, CES-D scores were comparable in PSI and NI patients (12.2 (9.3) vs. 10.5 (9.0) points, p = 0.08) as were their temporal changes (0.5 (8.3) vs. 1.3 (7.9) points, p = 0.30). Conclusion The ECLIPSE study does not support a strong relationship between PSI and symptoms of depression at baseline and after 36 months follow-up in COPD. Funding The study was sponsored by GlaxoSmithKline.

Published
2014

13. AIRWAY HYPERRESPONSIVENESS AND COPD MORTALITY

Author

Vestbo, J and Hansen, E F.

Subjects
Mortality -- Netherlands, Histamine -- Physiological aspects, Lung diseases, Obstructive -- Patient outcomes, Airway (Medicine) -- Physiological aspects, Health, Physiological aspects, Patient outcomes
Abstract

Introductory article Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study J J Hospers D S Postma B Rijcken S T Weiss J P Schouten Background: [...]

Published
2001

14. Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population

Author

Lange, P, Parner, J, Prescott, E, Ulrik, C Suppli, and Vestbo, J

Subjects
Hormone therapy -- Physiological aspects -- Health aspects, Progestational hormones -- Health aspects -- Physiological aspects, Asthma -- Risk factors, Health, Physiological aspects, Risk factors, Health aspects
Abstract

Abstract Background--Recent evidence suggests a role for hormonal factors in the aetiology of asthma. Methods--Data from a large study of women selected from the general population were used to relate [...]

Published
2001

17. Authors' reply

Author

Godtfredsen, N.S., Vestbo, J., Osler, M., Andersen, I., and Prescott, E.

Subjects
Health, Social sciences
Abstract

We appreciate the comments from Cope and Battersby on our paper reporting the association between smoking cessation and smoking reduction and subsequent risk of myocardial infarction. Specifically, they propose that [...]

Published
2004

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