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EXTENDED ANTICOAGULATION WITH APIXABAN OR DABIGATRAN REDUCES RECURRENT VTE AND MORTALITY WITHOUT INCREASING MAJOR BLEEDING Level 1: Likely reliable evidence Anticoagulation treatment for individuals with venous thromboembolism (VTE) is generally [...]

EXTENDED ANTICOAGULATION WITH APIXABAN OR DABIGATRAN REDUCES RECURRENT VTE AND MORTALITY WITHOUT INCREASING MAJOR BLEEDING Level 1: Likely reliable evidence Anticoagulation treatment for individuals with venous thromboembolism (VTE) is generally [...]

Description * Acute diarrhea is typically defined as change in normal bowel movement with unusually soft or liquid stools three or more times in 24 hours, lasting 14 days or [...]

Description * Deficiency of thyroid hormone with many and varied manifestations ICD-9 codes * 243 congenital hypothyroidism * 244 acquired hypothyroidism --244.0 postsurgical hypothyroidism --244.1 other postablative hypothyroidism --244.2 iodine [...]

Level 2: Mid-level evidence Acute respiratory infections are commonly encountered in primary care, and symptom control is often the chief concern of patients. The American College of Physicians recommends against [...]

NURSING PROTOCOLS FOR FEVER, HYPERGLYCEMIA, AND SWALLOWING MANAGEMENT IN PATIENTS WITH ACUTE STROKE MAY REDUCE DEPENDENCE Level 2: Mid-level evidence Fever, hyperglycemia, and swallowing dysfunction after an acute stroke have [...]

Level 2: Mid-level evidence In recent years, a number of evidence-based interventions for cardiovascular disease have been incorporated into clinical practice guidelines. A recent nationwide study in Sweden analyzed a [...]

Level 2 (mid-level) evidence Bisphosphonates are often recommended for postmenopausal women receiving aromatase inhibitor therapy for hormonereceptor-positive breast cancer with evidence of osteoporosis. Denosumab has previously been shown to reduce [...]

Level 2: Mid-level evidence Children can be at high risk of infections during hospital stays, and measures commonly used to prevent nosocomial infections (e.g., hand hygiene) are not completely effective. [...]

Level 2: Mid-level evidence Preoperative skin cleansing is routinely performed to reduce the risk of surgical-site infections. A recent randomized trial suggests that cleansing with chlorhexidine-alcohol may be more effective [...]

Level x (mid-level) evidence Thrombolysis with alteplase (tissue-type plasminogen activator, t-PA) given up to 3 hours after the onset of acute ischemic stroke is associated with an increased likelihood of [...]

Level 2: Mid-level evidence Post-thrombotic syndrome is a chronic disorder affecting 40% to 48% of patients during the first 2 years after acute symptomatic deep venous thrombosis (DVT) (Annals of [...]

Level 2: Mid-level evidence Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a serious problem in hospitals around the world, causing thousands of deaths every year. Many institutions have [...]

Level 1: Likely reliable evidence Diarrhea due to Clostridium difficile is among the most serious nosocomial infections. It is most commonly treated with either vancomycin or metronidazole, but symptoms can [...]

Aspirin has been linked to a reduction in the risk of certain colorectal cancers (N Engl J Med. 2007;356:2131-2142; available at www.nejm.org/doi/full/10.1056/NEJMoa067208, accessed January 15, 2011), but its effect on [...]

A surgical safety checklist developed by the WHO (available at whqlibdoc.who.int/publications/2009/9789241598590_eng_Checklist.pdf, accessed November 15, 2010) to facilitate communication and safety checks was associated with reduced surgical mortality in a before-and-after [...]

Level 1: Likely reliable evidence A recent Cochrane review evaluated the efficacy of various antihypertensive drugs given within 24 hours of acute MI (Cochrane Database Syst Rev. 2009 Oct 7;[4]:CD006743). [...]

Level 3: Lacking direct evidence CT scans provide much more detailed images than plain x-rays but expose patients to much higher doses of radiation. In a cross-sectional retrospective study of [...]

Level 1: Likely reliable evidence B-type natriuretic peptide (BNP) as well as its N-terminal fragment (NT-proBNP) can provide useful diagnostic and prognostic information in patients with acute dyspnea and chronic [...]

Level 1: Likely reliable evidence Elevated procalcitonin levels indicate an infection is more likely to be bacterial than viral in etiology. Several trials have shown that antibiotic usage can be [...]

Level 2: Mid-level evidence A recent observational study evaluated the malignancy rates associated with human insulin and insulin analog in 127, 031 adults with diabetes receiving first-time insulin monotherapy (Diabetologia. [...]