1. SARS-CoV-2 infection of the placenta
- Author
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Hosier, Hillary, Farhadian, Shelli F., Morotti, Raffaella A., Deshmukh, Uma, Lu-Culligan, Alice, Campbell, Katherine H., Yasumoto, Yuki, Vogels, Chantal B.F., Casanovas-Massana, Arnau, Vijayakumar, Pavithra, Geng, Bertie, Odio, Camila D., Fournier, John, Brito, Anderson F., Fauver, Joseph R., Liu, Feimei, Alpert, Tara, Tal, Reshef, Szigeti-Buck, Klara, Perincheri, Sudhir, Larsen, Christopher, Gariepy, Aileen M., Aguilar, Gabriela, Fardelmann, Kristen L., Harigopal, Malini, Taylor, Hugh S., Pettker, Christian M., Wyllie, Anne L., Dela Cruz, Charles, Ring, Aaron M., Grubaugh, Nathan D., Ko, Albert I., Horvath, Tamas L., Iwasaki, Akiko, Reddy, Uma M., and Lipkind, Heather S.
- Subjects
Severe acute respiratory syndrome -- Health aspects -- Analysis ,Coronaviruses -- Analysis -- Health aspects ,Venture capital companies -- Analysis -- Health aspects ,Pregnancy -- Analysis -- Health aspects ,Neonatology -- Analysis -- Health aspects ,Pregnant women -- Health aspects -- Analysis ,Tranexamic acid -- Health aspects -- Analysis ,COVID-19 -- Analysis -- Health aspects ,Health care industry - Abstract
BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19. FUNDING. Beatrice Kleinberg Neuwirth Fund and Fast Grant Emergent Ventures funding from the Mercatus Center at George Mason University. The funding bodies did not have roles in the design of the study or data collection, analysis, and interpretation and played no role in writing the manuscript., Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus causing the deadly pandemic of coronavirus disease 2019 (COVID-19). The risks and specific effects of SARS-CoV-2 in pregnant [...]
- Published
- 2020
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