Search

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL., T cell acute lymphoblastic leukemias (T-ALLs) are aggressive hematologic tumors resulting from the malignant transformation of T cell progenitors. T-ALL accounts for 10%-15% of pediatric and 25% of adult ALL [...]

The lymphoid tissues, including both the B and T cell lineages, are characterized by a unique level of biological complexity due to the anatomical organization of functionally distinct cell subpopulations and complex processes of genetic alteration required to generate immune responses. Not surprisingly, this physiological diversity and complexity is mirrored by the broad spectrum of malignancies derived from lymphocytes. The articles in this Review Series highlight recent progress in selected common lymphoid malignancies, with a focus on the genetic alterations that drive malignant transformation, including those identified by genomewide analyses. These genetic alterations represent the basis from which cellular pathways of therapeutic relevance can be identified, studied, and eventually targeted., Few other tissues in the body are characterized by the biological and functional complexity of the lymphoid system. Classically, lymphoid tissues can be divided into two types: (a) the central [...]