1. Clinical characteristics and early treatment outcomes of follicular lymphoma in young adults.
- Author
-
Gangatharan, Shane A., Maganti, Manjula, Kuruvilla, John G., Kukreti, Vishal, Tiedemann, Rodger E., Gospodarowicz, Mary K., Hodgson, David C., Sun, Alex, Tsang, Richard W., Pintilie, Melania, and Crump, Michael
- Subjects
LYMPHOMA treatment ,DISEASES in young adults ,LYMPHOMA diagnosis ,MEDICAL databases ,HEALTH outcome assessment - Abstract
Follicular lymphoma ( FL) in young adults ( YA, <40 years old) is uncommon, and the clinical characteristics and outcomes of this group are not well defined. We conducted a retrospective database review of 427 patients with newly diagnosed FL aged 65 years or less registered at Princess Margaret Cancer Centre between 1995 and 2010. YA ( n = 61) and those 40-65 ( n = 366) were compared with regards to clinical stage at diagnosis, FL International Prognostic Index ( FLIPI) score, and the following clinical outcomes: time to second treatment, cause-specific survival (CSS) and overall survival (OS). At diagnosis, stage and FLIPI score were similar, as were the proportion of patients requiring therapy ( YA 75% versus older adults 71%). Median follow-up was 8·1 years. Time to second therapy was similar in both age groups (5-year probability 23% YA versus 27% older adults; Gray's P-value = 0·76). Ten-year OS was significantly higher for YA (87% versus older adults 72%; P = 0·029). On multivariate analysis, age <40 years, low FLIPI score and observation as initial management were favourable prognostic factors for OS and CSS. We conclude that YA with FL have a favourable prognosis compared to older patients; whether this reflects competing mortality risks or age-related differences in lymphoma biology warrants further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF