1. Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.
- Author
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Berg LA, Rocha BM, Oliveira RS, Sebastian R, Rodriguez B, de Queiroz RAB, Cherry EM, and Dos Santos RW
- Subjects
- Humans, Cardiac Conduction System Disease, Heart Conduction System, Heart Ventricles, Heart, Benchmarking
- Abstract
Cardiac Purkinje networks are a fundamental part of the conduction system and are known to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje networks remains a challenge due to their high morphological complexity. This work presents a novel method based on optimization principles for the generation of Purkinje networks that combines geometric and activation accuracy in branch size, bifurcation angles, and Purkinje-ventricular-junction activation times. Three biventricular meshes with increasing levels of complexity are used to evaluate the performance of our approach. Purkinje-tissue coupled monodomain simulations are executed to evaluate the generated networks in a realistic scenario using the most recent Purkinje/ventricular human cellular models and physiological values for the Purkinje-ventricular-junction characteristic delay. The results demonstrate that the new method can generate patient-specific Purkinje networks with controlled morphological metrics and specified local activation times at the Purkinje-ventricular junctions., (© 2023. The Author(s).)
- Published
- 2023
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