1. Health-related quality of life after pediatric heart transplantation in early childhood.
- Author
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Garcia Guerra G, Bond GY, Joffe AR, Dinu IA, Hajihosseini M, Al-Aklabi M, Robertson CMT, and Urschel S
- Subjects
- Female, Follow-Up Studies, Humans, Infant, Male, Postoperative Period, Prospective Studies, Time Factors, Health Status, Heart Transplantation psychology, Quality of Life psychology
- Abstract
Background: There is limited information about HRQL after pediatric heart transplantation at a young age., Methods: Prospective follow-up study of children who received a heart transplant at age ≤4 years. HRQL was assessed using the PedsQL
TM 4.0 at age 4.5 years. This cohort was compared with healthy children, children with CHD, and with chronic conditions. Peri-operative factors associated with HRQL were also explored., Results: Of 66 eligible patients, 15 (23%) died prior to the HRQL assessment and 2 (3%) were lost to follow-up, leaving 49 patients. Indication for transplantation was CHD in 27 (55%) and CMP in 22 (45%). Median age (IQR) at transplant was 9 (5-31) months. HRQL was significantly lower in transplanted children compared to population norms (65.3 vs 87.3, P < .0001), children with chronic conditions (65.3 vs 76.1, P = .001), and children with CHD (65.3 vs 81.1, P < .0001). Transplanted children with CHD had lower HRQL than those with a prior diagnosis of CMP (59.5 vs 72.5, P-value = .020). Higher creatinine pretransplant and higher lactate post-operatively were associated with lower HRQL., Conclusion: Children after heart transplant had significantly lower HRQL, as reported by their parents, than the normative population, children with chronic conditions, and children with CHD., (© 2020 Wiley Periodicals LLC.)- Published
- 2020
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