1. Early detection of HVAD pump thrombosis based on technical analysis and power consumption measurements.
- Author
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Krysiński M, Gawlikowski M, Biełka A, Krysińska M, Małyszek-Tumidajewicz J, Copik I, Pacholewicz J, Zembala M, and Zembala M
- Subjects
- Humans, Retrospective Studies, Heart Failure diagnosis, Heart Failure surgery, Heart Transplantation, Heart-Assist Devices adverse effects, Thromboembolism etiology, Thrombosis diagnosis, Thrombosis etiology, Thrombosis therapy
- Abstract
Background: Continuous-flow left ventricular assist devices (LVADs) have been extensively used in a strategy of bridge to orthotopic heart transplant and destination therapy. The usage of LVAD, however, is not free from limitations such as device-related adverse events, including pump thrombosis (PT). We aimed to develop an algorithm of early PT detection based on the maintenance parameters monitored by the implanted device., Methods: We analyzed log files of 101 patients implanted with HeartWare pump (HVAD) with 18 PT events among them. For signal processing, we used the open-high-low-close format transformation and typical price (TP) technical analysis indicator. Model parameters were tuned with 5-fold cross-validation, and the final performance was measured on a separate group of patients., Results: Our algorithm achieved 100% sensitivity and 100% specificity of indications. In the final evaluation, alarms preceded the clinical acknowledgement of events by 2 days and 20 h on average. In the worst-case scenario, an alarm was raised 1 day and 8 h prior to the event., Conclusions: The proposed algorithm could be installed to work directly with the device controller and provide clinicians with automatic readings analysis, raising an alarm when there is a high probability of thromboembolism. Early event detection could enable better thrombosis management and improve prognosis in patients implanted with HVAD., (© 2022 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC.)
- Published
- 2022
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