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A study of multiple-ion therapy with charged heavy-ion beams was performed to improve outcomes of refractory cancer treatments. We proposed the accelerator operation method for applying the multiple-ion therapy, to quickly switch the ion species and energies of the output beams. In this method, the irradiation ion species can be changed only by switching the selected ion source and the injector parameters, and the output beam energies can be varied without changing the magnetic operation patterns of the synchrotron. We verified the effectiveness of our approach by conducting experiments at the Heavy Ion Medical Accelerator in Chiba (HIMAC) and confirmed that the approach can provide the fast switching of both the ion species and the beam energies. The experimental results also demonstrated that our approach will greatly reduce the commissioning time and the routine adjustments for multiple-ion beams. [ABSTRACT FROM AUTHOR]

Abstract: In order to realize a precise dose distribution in heavy-ion cancer therapy, high beam stability is required for the accelerator complex. Owing to load fluctuation caused by the upper ring, which is one of the two rings in HIMAC, current dips of ≈5–10Hz were observed in the power supply for the bending/quadrupole magnet of the other lower ring. The parameters of the beam stability, such as the spill variation, the beam position, and the size, were adversely affected by the current dips. In order to suppress these current dips, we developed a new feed-forward system in the magnet power supply. We verified the performance of the feed-forward system by measuring the suppression of the current dips. We also performed beam experiments to measure the variation of the horizontal tune and the structure of the beam spill, which is slowly extracted by the resonance method. The experimental result showed that the current dips were successfully reduced by the system to ΔI/I ∼10−6. It was also confirmed that the horizontal tune and the spill structure could be stabilized by the current dip suppression. [Copyright &y& Elsevier]