9 results on '"Luo, Xiao-San"'
Search Results
2. Effects of elevated carbon dioxide on metal transport in soil-crop system: results from a field rice and wheat experiment
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Luo, Xiao-San, Zhang, Dan, Hu, Zhenghua, Liu, Chao, Zhao, Zhen, Sun, Wenjuan, Fang, Xiaokun, and Fan, Peipei
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- 2019
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3. Summer–winter differences of PM2.5 toxicity to human alveolar epithelial cells (A549) and the roles of transition metals.
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Chen, Yan, Luo, Xiao-San, Zhao, Zhen, Chen, Qi, Wu, Di, Sun, Xue, Wu, Lichun, and Jin, Ling
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EPITHELIAL cells ,TRANSITION metals ,CELL survival ,OXIDATIVE stress ,ATMOSPHERIC aerosols - Abstract
Abstract Atmospheric fine particulate matters (PM 2.5) induce adverse human health effects through inhalation, and the harmful effects of PM 2.5 are determined not only by its air concentrations, but also by the particle components varied temporally. To investigate seasonal differences of the aerosol toxicity effects including cell viability and membrane damage, cell oxidative stress and responses of inflammatory cytokines, the human lung epithelial cells (A549) were exposed to PM 2.5 samples collected in both summer and winter by the in vitro toxicity bioassays. Toxicological results showed that, the PM 2.5 led to the cell viability decrease, cell membrane injury, oxidative stress level increase and inflammatory responses in a dose-dependent manner. Temporally, the cytotoxicity of winter PM 2.5 was higher than summer of this studied industrial area of Nanjing, China. According to the different contents of heavy metals accumulated in PM 2.5 , the transition metals such as Cu might be an important contributor to the aerosol cell toxicity. Highlights • In vitro toxicity of PM 2.5 showed seasonal differences. • PM 2.5 from different seasons showed varied metal components. • Transition metals in PM 2.5 contribute to the particle cell toxicity. • Health risks of PM 2.5 should consider composition and source effects. • Toxicity of winter PM 2.5 from Nanjing was higher than summer. [ABSTRACT FROM AUTHOR]
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- 2018
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4. Source identification and apportionment of heavy metals in urban soil profiles.
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Luo, Xiao-San, Xue, Yan, Wang, Yan-Ling, Cang, Long, Xu, Bo, and Ding, Jing
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HEAVY metals , *SOIL composition , *SOIL pollution prevention , *LEAD isotopes , *MULTIPLE correspondence analysis (Statistics) , *REGRESSION analysis ,URBAN ecology (Sociology) - Abstract
Because heavy metals (HMs) occurring naturally in soils accumulate continuously due to human activities, identifying and apportioning their sources becomes a challenging task for pollution prevention in urban environments. Besides the enrichment factors (EFs) and principal component analysis (PCA) for source classification, the receptor model (Absolute Principal Component Scores-Multiple Linear Regression, APCS-MLR) and Pb isotopic mixing model were also developed to quantify the source contribution for typical HMs (Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn) in urban park soils of Xiamen, a representative megacity in southeast China. Furthermore, distribution patterns of their concentrations and sources in 13 soil profiles (top 20 cm) were investigated by different depths (0–5, 5–10, 10–20 cm). Currently the principal anthropogenic source for HMs in urban soil of China is atmospheric deposition from coal combustion rather than vehicle exhaust. Specifically for Pb source by isotopic model ( 206 Pb/ 207 Pb and 208 Pb/ 207 Pb), the average contributions were natural (49%) > coal combustion (45%) ≫ traffic emissions (6%). Although the urban surface soils are usually more contaminated owing to recent and current human sources, leaching effects and historic vehicle emissions can also make deep soil layer contaminated by HMs. [ABSTRACT FROM AUTHOR]
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- 2015
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5. Solid/solution partitioning and speciation of heavy metals in the contaminated agricultural soils around a copper mine in eastern Nanjing city, China
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Luo, Xiao-San, Zhou, Dong-Mei, Liu, Xiao-Hong, and Wang, Yu-Jun
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HEAVY metals , *PARTITION coefficient (Chemistry) , *SOIL moisture , *ARABLE land - Abstract
Abstract: Solid/solution partition coefficient (K d) and speciation of soil heavy metals can be used for predicting their environmental risks. The K d values and solution speciation of soil Cu, Cd and Zn were analyzed in 40 samples of contaminated agricultural soils around Jiuhua copper mine in eastern Nanjing city, China. The K d ranges (and mean values) for soil Cu, Cd and Zn are 703–7418 (3453), 37.3–3963 (940) and 319–17965 (7244)Lkg−1, respectively, showing a large variability both for metals and soils. The results of differential pulse anodic stripping voltammetry (DPASV) indicates that 95.6% solution Cu is bound to dissolved organic ligands. About half of the dissolved Zn is DPASV-labile at pH<6, while 92.1% solution Zn is in the form of organic complexes at pH>6. DPASV-labile Cd is ranged from 22.6 to 98.7% with the mean value of 56.3%. Multiple linear regressions indicate that K d, the dissolved and DPASV-labile concentrations of Cd and Zn are mostly influenced by the soil solution pH with R 2 of 0.50, 0.59 and 0.63, respectively for Cd, and 0.58, 0.72 and 0.64, respectively for Zn. Considering the second parameter of corresponding soil metal, the linear relationships of K d with pH were improved with R 2 of 0.70 and 0.73 for Cd and Zn, respectively. However, the solubility of soil Cu was insensitive to pH. Only SOC shows a weak relationship to the dissolved Cu with R 2 of 0.21. As for its K d, total soil Cu is the most significant factor. But for DPASV-labile Cu, no soil parameters were found to be good predictors. [Copyright &y& Elsevier]
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- 2006
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6. Seasonal and areal variability in PM2.5 poses differential degranulation and pro-inflammatory effects on RBL-2H3 cells.
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Tang, Mingwei, Luo, Xiao-San, Huang, Weijie, Pang, Yuting, Hong, Youwei, Chen, Jinsheng, Wu, Lichun, and Pinkerton, Kent E.
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ENDOTOXINS , *SUBURBS , *BIOMASS burning , *HEAVY metals , *ENVIRONMENTAL health , *INORGANIC compounds - Abstract
PM 2.5 pollution is a widespread environmental and health problem, particularly in China. Besides leading to well-known diseases in the respiratory system, PM 2.5 can also alter immune function to induce or aggravate allergic diseases. To determine whether there are temporal and spatial differences in the allergic responses to PM 2.5 , monthly samples were collected from four regions (urban, industrial, suburban, and rural areas) through a whole year in Nanjing city, China. Inorganic chemical components (metals and water-soluble ions) of PM 2.5 were analyzed, and the rat basophil cells (RBL-2H3) exposed to PM 2.5 were assessed through quantitative measures of degranulation (β-hex and histamine) and pro-inflammation cytokine (IL-4 and TNF-α) expression. The highest levels of β-hex were measured in winter and spring PM 2.5 from urban and industrial areas, or autumn PM 2.5 from suburban and rural areas. With respect to histamine, autumn PM 2.5 samples were most potent irrespective of the location. Autumn and winter PM 2.5 induced higher levels of IL-4 than spring and summer samples. However, spring and autumn PM 2.5 caused higher levels of TNF-α. The concentrations of water-soluble ions (NH 4 +, K+ and Cl−), as well as heavy metals (Pb and Cr), were directly and statistically correlated to the inflammation observed in vitro. In general, the differences between regional and seasonal PM 2.5 in stimulating cell degranulation may depend on endotoxin and airborne allergen content of PM 2.5. The heavy metals and water-soluble ions in PM 2.5 were mostly anthropogenic, which increased the particles' mass-based cellular inflammatory potential, therefore, their health risks, e.g. from vehicular exhaust, coal, and biomass combustion, cannot be ignored. [Display omitted] • PM 2.5 could directly enhance β-hexosaminidase release by basophilic cells. • Degranulation of basophil cells exposed to PM 2.5 show regional and seasonal variations. • PM 2.5 shows the strong pro-inflammation effect on basophilic cells. • Airborne heavy metals and water-soluble ions correlate positively with cell inflammatory response. • PM 2.5 -induced cellular inflammation was driven by anthropogenic sources. [ABSTRACT FROM AUTHOR]
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- 2021
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7. In vitro assessments of bioaccessibility and bioavailability of PM2.5 trace metals in respiratory and digestive systems and their oxidative potential.
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Zhao, Zhen, Luo, Xiao-San, Jing, Yuanshu, Li, Hongbo, Pang, Yuting, Wu, Lichun, Chen, Qi, and Jin, Ling
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TRACE metals , *RESPIRATORY organs , *DIGESTIVE organs , *BIOAVAILABILITY , *TRANSITION metals , *HEAVY metals , *TOXICITY testing - Abstract
Air pollution is a serious environmental issue. As a key aerosol component, PM 2.5 associated toxic trace metals pose significant health risks by inhalation and ingestion, but the evidences and mechanisms were insufficient and not well understood just by their total environmental concentrations. To accurately assess the potential risks of airborne metals, a series of in vitro physiologically based tests with synthetic human lung and gastrointestinal fluids were conducted to assess both the bioaccessibility and bioavailability of various PM 2.5 bound metals in the respiratory and digestive systems from both urban and industrial areas of Nanjing city. Moreover, the chemical acellular toxicity test [dithiothreitol (DTT) assay] and source analysis were performed. Generally, the bioaccessibility and bioavailability of investigated metals were element and body fluid dependent. Source oriented metals in PM 2.5 showed diverse bioaccessibility in different human organs. The PM 2.5 induced oxidative potential was mainly contributed by the bioaccessible/bioavailable transition metals such as Fe, Ni and Co from metallurgic dust and traffic emission. Future researches on the toxicological mechanisms of airborne metals incorporating the bioaccessibility, bioavailability and toxicity tests are directions. ga1 • Bioaccessibility and bioavailability of airborne metals were compared sequentially. • Metals dissolved in respiratory–digestive systems were element and fluid dependent. • Source-dependent PM 2.5 metals pose varied bioaccessibility/bioavailability in organs. • Bioaccessible/bioavailable transition metals induce PM 2.5 oxidative potential. • Metal bioaccessibility/bioavailability explain aerosol toxicity and health risks. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Toxicity assessment and heavy metal components of inhalable particulate matters (PM2.5 & PM10) during a dust storm invading the city.
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Zhang, Dong, Li, Hanhan, Luo, Xiao-San, Huang, Weijie, Pang, Yuting, Yang, Jinshan, Tang, Mingwei, Mehmood, Tariq, and Zhao, Zhen
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HEAVY metal toxicology , *PARTICULATE matter , *DUST storms , *SUBURBS , *AIR pollution , *EPITHELIAL cells - Abstract
Dust storm (DS) represent global air pollution and health issues considering the high morbidity and premature death rate every year. This study explores the characteristics, composition, and variations in inhalable particulate matters (PMs) as well as their corresponding in vitro toxicity to human lung epithelial cells (A549) during DS and normal days (ND) in the downtown (DT) and the north suburban (NS) of Nanjing city, eastern China. Results showed that compared to ND, concentrations of heavy metals (i.e., Cr, Cu, Ni, and Pb) bound in PMs were lower during the DS. Furthermore, the relationship of cytotoxicity with Ni and Pb levels in PMs was significant. However, the cytotoxicity difference was insignificant between NS and DT. This may be due to the long-range transport of components from natural sources mixed with local pollutants emitted from anthropogenic sources, offsetting the pollution difference between urban and suburban areas. During both periods, PM 2.5 toxicity was greater than PM 10 , while the potential of PM 10 to induce proinflammatory cytokines was comparable to PM 2.5. Results suggested that inflammation risk will increase significantly during DS due to a substantial increase in ambient air PM 10 concentration. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2022
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9. Seasonal Levels, Sources, and Health Risks of Heavy Metals in Atmospheric PM2.5 from Four Functional Areas of Nanjing City, Eastern China.
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Wu, Lichun, Luo, Xiao-San, Li, Hongbo, Cang, Long, Yang, Jie, Yang, Jiangli, Zhao, Zhen, and Tang, Mingwei
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HEAVY metals , *HEALTH risk assessment , *SUBURBS , *HEAVY metal toxicology , *MULTIPLE correspondence analysis (Statistics) , *CITIES & towns - Abstract
Aerosol pollution is a serious environmental issue, especially in China where there has been rapid urbanization. To identify the intra-annual and regional distributions of health risks and potential sources of heavy metals in atmospheric particles with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5), this work collected monthly PM2.5 samples from urban, industrial, suburban, and rural areas in Nanjing city during 2016 and analyzed the heavy metal compositions (Cu, Pb, Cd, Co, V, Sr, Mn, Ti, and Sb). Enrichment factors (EFs) and principal component analysis (PCA) were applied to investigate the sources. The atmospheric PM2.5 pollution level was highest in the industrial area, followed by the urban and suburban areas, and was the lowest in the rural area. Seasonally, the concentrations of PM2.5 and associated heavy metals in spring and winter were higher than those in summer and autumn. Besides natural sources, heavy metal pollution in PM2.5 might come from metallurgical dust in the industrial area, while it mainly comes from automobile exhaust in urban and suburban areas. Health risk assessments revealed that noncancerous hazards of heavy metals in PM2.5 were low, while the lifetime cancer risks obviously exceeded the threshold. The airborne metal pollution in various functional areas of the city impacted human health differently. [ABSTRACT FROM AUTHOR]
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- 2019
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