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Your search keyword '"Pawliczak D"' showing total 2 results
Start Over Author "Pawliczak D" Topic hematologic neoplasms
2 results on '"Pawliczak D"'

1. Role of donor HLA class I mismatch, KIR-ligand mismatch and HLA:KIR pairings in hematological malignancy relapse after unrelated hematopoietic stem cell transplantation.

Author

Graczyk-Pol E, Rogatko-Koros M, Nestorowicz K, Gwozdowicz S, Mika-Witkowska R, Pawliczak D, Zubala M, Szlendak U, Witkowska A, Tomaszewska A, Nasilowska-Adamska B, Szczepinski A, Wojcik M, Halaburda K, and Nowak J

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Gene Expression, Graft vs Host Disease immunology, Graft vs Host Disease mortality, Graft vs Host Disease pathology, Hematologic Neoplasms drug therapy, Hematologic Neoplasms mortality, Hematologic Neoplasms pathology, Histocompatibility Antigens Class I genetics, Histocompatibility Testing, Humans, Infant, Killer Cells, Natural immunology, Killer Cells, Natural pathology, Male, Middle Aged, Myeloablative Agonists therapeutic use, Receptors, KIR genetics, Recurrence, Survival Analysis, Transplantation Conditioning methods, Transplantation, Homologous, Unrelated Donors, Graft vs Host Disease diagnosis, Hematologic Neoplasms diagnosis, Hematopoietic Stem Cell Transplantation mortality, Histocompatibility Antigens Class I immunology, Models, Immunological, Receptors, KIR immunology
Abstract

HLA are functional in cancer immunosurveillance in adaptive and innate immunity pathways. In unrelated hematopoietic stem cell transplantation (HSCT) in 688 patients with hematological malignancies we compared antitumor efficacy of transplant in three models including the level of: (a) donor-recipient HLA class I mismatch, (b) KIR-ligand mismatch, (c) post-transplant cognate HLA:KIR pairing. The effects were directly compared in multivariate models with backward elimination including all three effects in initial model. In final multivariate model HLA mismatch and KIR-ligand mismatch levels were eliminated and HLA:KIR-dependent NK cell licensing effect remained independent prognostic factor for DFS, relapse/progression incidence, and overall survival (OS). These results suggested that NK cell licensing via cognate HLA:KIR pairs is primarily functional in cancer immunosurveillance in HSCT., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2018
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2. HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor.

Author

Nowak J, Nestorowicz K, Graczyk-Pol E, Mika-Witkowska R, Rogatko-Koros M, Jaskula E, Koscinska K, Madej S, Tomaszewska A, Nasilowska-Adamska B, Szczepinski A, Halaburda K, Dybko J, Kuliczkowski K, Czerw T, Giebel S, Holowiecki J, Baranska M, Pieczonka A, Wachowiak J, Czyz A, Gil L, Lojko-Dankowska A, Komarnicki M, Bieniaszewska M, Kucharska A, Hellmann A, Gronkowska A, Jedrzejczak WW, Markiewicz M, Koclega A, Kyrcz-Krzemien S, Mielcarek M, Kalwak K, Styczynski J, Wysocki M, Drabko K, Wojcik B, Kowalczyk J, Gozdzik J, Pawliczak D, Gwozdowicz S, Dziopa J, Szlendak U, Witkowska A, Zubala M, Gawron A, Warzocha K, and Lange A

Subjects
Adolescent, Adult, Alleles, Child, Child, Preschool, Female, Graft vs Host Disease immunology, Graft vs Host Disease mortality, HLA Antigens immunology, Hematologic Neoplasms mortality, Humans, Infant, Isoantigens immunology, Male, Middle Aged, Polymorphism, Genetic, Prognosis, Survival Analysis, Treatment Outcome, Young Adult, Graft vs Host Disease diagnosis, Haplotypes genetics, Hematologic Neoplasms therapy, Hematopoietic Stem Cell Transplantation, Histocompatibility
Abstract

Serious risks in unrelated hematopoietic stem cell transplantation (HSCT) including graft versus host disease (GvHD) and mortality are associated with HLA disparity between donor and recipient. The increased risks might be dependent on disparity in not-routinely-tested multiple polymorphisms in genetically dense MHC region, being organized in combinations of two extended MHC haplotypes (Ehp). We assessed the clinical role of donor-recipient Ehp disparity levels in N = 889 patients by the population-based detection of HLA allele phase mismatch. We found increased GvHD incidences and mortality rates with increasing Ehp mismatch level even with the same HLA mismatch level. In multivariate analysis HLA mismatch levels were excluded from models and Ehp disparity level remained independent prognostic factor for high grade acute GvHD (p = 0.000037, HR = 10.68, 95%CI 5.50-32.5) and extended chronic GvHD (p < 0.000001, HR = 15.51, CI95% 5.36-44.8). In group with single HLA mismatch, patients with double Ehp disparity had worse 5-year overall survival (45% vs. 56%, p = 0.00065, HR = 4.05, CI95% 1.69-9.71) and non-relapse mortality (40% vs. 31%, p = 0.00037, HR = 5.63, CI95% 2.04-15.5) than patients with single Ehp disparity. We conclude that Ehp-linked factors contribute to the high morbidity and mortality in recipients given HLA-mismatched unrelated transplant and Ehp matching should be considered in clinical HSCT., (Copyright © 2018. Published by Elsevier Inc.)

Published
2018
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